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Literature summary for 1.14.13.8 extracted from

  • Taniguchi-Takizawa, T.; Kato, N.; Shimizu, M.; Kume, T.; Yamazaki, H.
    Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes (2021), Drug Metab. Pharmacokinet., 40, 100412 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
benzydamine + NADPH + H+ + O2 Homo sapiens
-
benzydamine N-oxide + NADP+ + H2O
-
?
chlorpromazine + NADPH + H+ + O2 Homo sapiens
-
chlorpromazine N-oxide + NADP+ + H2O
-
?
clomipramine + NADPH + H+ + O2 Homo sapiens
-
clomipramine N-oxide + NADP+ + H2O
-
?
clozapine + NADPH + H+ + O2 Homo sapiens
-
clozapine N-oxide + NADP+ + H2O
-
?
dasatinib + NADPH + H+ + O2 Homo sapiens
-
dasatinib N-oxide + NADP+ + H2O
-
?
itopride + NADPH + H+ + O2 Homo sapiens
-
itopride N-oxide + NADP+ + H2O
-
?
loxapine + NADPH + H+ + O2 Homo sapiens
-
loxapine N-oxide + NADP+ + H2O
-
?
additional information Homo sapiens comparison of in vivo activity of FMO enzyme with P450 enzme in N-oxygenation of drugs at different pH values, overview ?
-
-
N,N-dimethylaniline + NADPH + H+ + O2 Homo sapiens
-
N,N-dimethylaniline N-oxide + NADP+ + H2O
-
?
tamoxifen + NADPH + H+ + O2 Homo sapiens
-
tamoxifen N-oxide + NADP+ + H2O
-
?
tozasertib + NADPH + H+ + O2 Homo sapiens
-
tozasertib N-oxide + NADP+ + H2O
-
?
trimethylamine + NADPH + H+ + O2 Homo sapiens
-
trimethylamine N-oxide + NADP+ + H2O
-
?
xanomeline + NADPH + H+ + O2 Homo sapiens
-
xanomeline N-oxide + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P31513
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzydamine + NADPH + H+ + O2
-
Homo sapiens benzydamine N-oxide + NADP+ + H2O
-
?
chlorpromazine + NADPH + H+ + O2
-
Homo sapiens chlorpromazine N-oxide + NADP+ + H2O
-
?
clomipramine + NADPH + H+ + O2
-
Homo sapiens clomipramine N-oxide + NADP+ + H2O
-
?
clozapine + NADPH + H+ + O2
-
Homo sapiens clozapine N-oxide + NADP+ + H2O
-
?
dasatinib + NADPH + H+ + O2
-
Homo sapiens dasatinib N-oxide + NADP+ + H2O
-
?
itopride + NADPH + H+ + O2
-
Homo sapiens itopride N-oxide + NADP+ + H2O
-
?
loxapine + NADPH + H+ + O2
-
Homo sapiens loxapine N-oxide + NADP+ + H2O
-
?
additional information comparison of in vivo activity of FMO enzyme with P450 enzme in N-oxygenation of drugs at different pH values, overview Homo sapiens ?
-
-
N,N-dimethylaniline + NADPH + H+ + O2
-
Homo sapiens N,N-dimethylaniline N-oxide + NADP+ + H2O
-
?
tamoxifen + NADPH + H+ + O2
-
Homo sapiens tamoxifen N-oxide + NADP+ + H2O
-
?
tozasertib + NADPH + H+ + O2
-
Homo sapiens tozasertib N-oxide + NADP+ + H2O
-
?
trimethylamine + NADPH + H+ + O2
-
Homo sapiens trimethylamine N-oxide + NADP+ + H2O
-
?
xanomeline + NADPH + H+ + O2
-
Homo sapiens xanomeline N-oxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase
-
Homo sapiens
flavin-containing monooxygenase 3
-
Homo sapiens
FMO
-
Homo sapiens
FMO3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
malfunction genetic mutations in FMO3 can cause trimethylaminuria (or fish-odor syndrome) as a result of impaired N-oxygenation of food-derived trimethylamine Homo sapiens
metabolism flavin-containing monooxygenase (FMO) 3 is a member of a family of NADPH-dependent enzymes that oxygenate a range of highly polarizable soft nucleophilic heteroatom-containing substances. Human liver FMO3 potentially forms a complementary enzyme system to the NADPH-dependent cytochrome P450 enzymes (P450s, EC 1.14.14.1) responsible for drug metabolism Homo sapiens