Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzydamine + NADPH + H+ + O2 | Homo sapiens | - |
benzydamine N-oxide + NADP+ + H2O | - |
? | |
chlorpromazine + NADPH + H+ + O2 | Homo sapiens | - |
chlorpromazine N-oxide + NADP+ + H2O | - |
? | |
clomipramine + NADPH + H+ + O2 | Homo sapiens | - |
clomipramine N-oxide + NADP+ + H2O | - |
? | |
clozapine + NADPH + H+ + O2 | Homo sapiens | - |
clozapine N-oxide + NADP+ + H2O | - |
? | |
dasatinib + NADPH + H+ + O2 | Homo sapiens | - |
dasatinib N-oxide + NADP+ + H2O | - |
? | |
itopride + NADPH + H+ + O2 | Homo sapiens | - |
itopride N-oxide + NADP+ + H2O | - |
? | |
loxapine + NADPH + H+ + O2 | Homo sapiens | - |
loxapine N-oxide + NADP+ + H2O | - |
? | |
additional information | Homo sapiens | comparison of in vivo activity of FMO enzyme with P450 enzme in N-oxygenation of drugs at different pH values, overview | ? | - |
- |
|
N,N-dimethylaniline + NADPH + H+ + O2 | Homo sapiens | - |
N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
tamoxifen + NADPH + H+ + O2 | Homo sapiens | - |
tamoxifen N-oxide + NADP+ + H2O | - |
? | |
tozasertib + NADPH + H+ + O2 | Homo sapiens | - |
tozasertib N-oxide + NADP+ + H2O | - |
? | |
trimethylamine + NADPH + H+ + O2 | Homo sapiens | - |
trimethylamine N-oxide + NADP+ + H2O | - |
? | |
xanomeline + NADPH + H+ + O2 | Homo sapiens | - |
xanomeline N-oxide + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31513 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzydamine + NADPH + H+ + O2 | - |
Homo sapiens | benzydamine N-oxide + NADP+ + H2O | - |
? | |
chlorpromazine + NADPH + H+ + O2 | - |
Homo sapiens | chlorpromazine N-oxide + NADP+ + H2O | - |
? | |
clomipramine + NADPH + H+ + O2 | - |
Homo sapiens | clomipramine N-oxide + NADP+ + H2O | - |
? | |
clozapine + NADPH + H+ + O2 | - |
Homo sapiens | clozapine N-oxide + NADP+ + H2O | - |
? | |
dasatinib + NADPH + H+ + O2 | - |
Homo sapiens | dasatinib N-oxide + NADP+ + H2O | - |
? | |
itopride + NADPH + H+ + O2 | - |
Homo sapiens | itopride N-oxide + NADP+ + H2O | - |
? | |
loxapine + NADPH + H+ + O2 | - |
Homo sapiens | loxapine N-oxide + NADP+ + H2O | - |
? | |
additional information | comparison of in vivo activity of FMO enzyme with P450 enzme in N-oxygenation of drugs at different pH values, overview | Homo sapiens | ? | - |
- |
|
N,N-dimethylaniline + NADPH + H+ + O2 | - |
Homo sapiens | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
tamoxifen + NADPH + H+ + O2 | - |
Homo sapiens | tamoxifen N-oxide + NADP+ + H2O | - |
? | |
tozasertib + NADPH + H+ + O2 | - |
Homo sapiens | tozasertib N-oxide + NADP+ + H2O | - |
? | |
trimethylamine + NADPH + H+ + O2 | - |
Homo sapiens | trimethylamine N-oxide + NADP+ + H2O | - |
? | |
xanomeline + NADPH + H+ + O2 | - |
Homo sapiens | xanomeline N-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flavin-containing monooxygenase | - |
Homo sapiens |
flavin-containing monooxygenase 3 | - |
Homo sapiens |
FMO | - |
Homo sapiens |
FMO3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | genetic mutations in FMO3 can cause trimethylaminuria (or fish-odor syndrome) as a result of impaired N-oxygenation of food-derived trimethylamine | Homo sapiens |
metabolism | flavin-containing monooxygenase (FMO) 3 is a member of a family of NADPH-dependent enzymes that oxygenate a range of highly polarizable soft nucleophilic heteroatom-containing substances. Human liver FMO3 potentially forms a complementary enzyme system to the NADPH-dependent cytochrome P450 enzymes (P450s, EC 1.14.14.1) responsible for drug metabolism | Homo sapiens |