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Literature summary for 1.14.13.8 extracted from

  • Allerston, C.K.; Shimizu, M.; Fujieda, M.; Shephard, E.A.; Yamazaki, H.; Phillips, I.R.
    Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3) (2007), Pharmacogenet. Genomics, 17, 827-839.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene fMO3, DNA and amino acid sequence determination and analysis of wild-type and natural mutant enzymes, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
E158K loss of function mutation of FMO3 results in trimethylaminuria or fish-odor-syndrome, the mutant enzyme is incapable of metabolizing trimethylamine to its non-odorous N-oxide, phenotype, overview Homo sapiens
E308G loss of function mutation of FMO3 results in trimethylaminuria or fish-odor-syndrome, the mutant enzyme is incapable of metabolizing trimethylamine to its non-odorous N-oxide, phenotype, overview Homo sapiens
additional information several single nucleotide polymorphisms cause loss of function mutation of FMO3 resulting in trimethylaminuria or fish-odor-syndrome, the mutant enzymes are incapable of metabolizing trimethylamine to its non-odorous N-oxide, haplotypes and phenotypes, overview Homo sapiens
R205C loss of function mutation of FMO3 results in trimethylaminuria or fish-odor-syndrome, the mutant enzyme is incapable of metabolizing trimethylamine to its non-odorous N-oxide, phenotype, overview Homo sapiens
V257M loss of function mutation of FMO3 results in trimethylaminuria or fish-odor-syndrome, the mutant enzyme is incapable of metabolizing trimethylamine to its non-odorous N-oxide, phenotype, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31513 FMO3
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Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase 3
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Homo sapiens
FMO3
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Homo sapiens