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Literature summary for 1.14.13.8 extracted from
- Tigecycline is modified by the flavin-dependent monooxygenase TetX (2005), Biochemistry, 44, 11829-11835.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene tetX, expression in Escherichia coli confers antibiotic resistance | Bacteroides fragilis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Bacteroides fragilis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bacteroides fragilis | tigecycline displays a broad spectrum of antibacterial activity and circumvents the efflux and ribosomal protection resistance mechanisms, Mg2+-complexing is required for ribosome binding, 11a-hydroxytigecycline forms a weaker complex with magnesium than tigecycline, structure, overview | ? | - |
? | |
| tigecycline + NADPH + O2 | Bacteroides fragilis | detoxification, the organism is resistant against the antibiotic | 11a-hydroxytigecycline + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacteroides fragilis | - |
gene tetX | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | tigecycline displays a broad spectrum of antibacterial activity and circumvents the efflux and ribosomal protection resistance mechanisms, Mg2+-complexing is required for ribosome binding, 11a-hydroxytigecycline forms a weaker complex with magnesium than tigecycline, structure, overview | Bacteroides fragilis | ? | - |
? | |
| tigecycline + NADPH + O2 | detoxification, the organism is resistant against the antibiotic | Bacteroides fragilis | 11a-hydroxytigecycline + NADP+ + H2O | - |
? | |
| tigecycline + NADPH + O2 | a glycylcycline derivative containing a 9-tert-butylglycylamido group belonging to the tetracyline antibiotic compounds | Bacteroides fragilis | 11a-hydroxytigecycline + NADP+ + H2O | product identification by LC-MS | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FMO | - |
Bacteroides fragilis |
| TetX | - |
Bacteroides fragilis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bacteroides fragilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Bacteroides fragilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | enzyme-bound | Bacteroides fragilis | |
| NADPH | required | Bacteroides fragilis | |
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Release 2023.1 (January 2023)
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