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Literature summary for 1.14.13.8 extracted from

  • Stevens, J.C.; Melton, R.J.; Zaya, M.J.; Engel, L.C.
    Expression and characterization of functional dog flavin-containing monooxygenase 1 (2003), Mol. Pharmacol., 63, 271-275.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
using a baculovuirus expression system in Sf-9 insect cells, dFMO1 is expressed to protein levels of 0.4 nM/mg Homo sapiens
using a baculovuirus expression system in Sf-9 insect cells, dFMO1 is expressed to protein levels of 0.4 nM/mg Canis lupus familiaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0047
-
imipramine 37°C Canis lupus familiaris
0.0078
-
imipramine 37°C Homo sapiens
0.0871
-
p-tolyl sulfide 37°C Homo sapiens
0.0986
-
p-tolyl sulfide 37°C Canis lupus familiaris

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
beagle
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
imipramine + NADPH + O2
-
Homo sapiens imipramine N-oxide + NADP+ + H2O
-
?
imipramine + NADPH + O2
-
Canis lupus familiaris imipramine N-oxide + NADP+ + H2O
-
?
p-tolyl sulfide + NADPH + O2 S-oxidase activity Homo sapiens p-tolyl sulfoxide + NADP+ + H2O
-
?
p-tolyl sulfide + NADPH + O2 S-oxidase activity Canis lupus familiaris p-tolyl sulfoxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase 1
-
Homo sapiens
flavin-containing monooxygenase 1
-
Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
p-tolyl sulfide S-oxidase activity Homo sapiens
8.8
-
imipramine N-oxidase activity Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7.6 9 pH 7.6: about 70% of maximal activity, pH 9.0: about 65% of maximal activity, p-tolyl sulfide S-oxidase activity Homo sapiens
7.6 9 S-oxidase activity incrases from pH 7.6-9.0 Canis lupus familiaris

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Canis lupus familiaris