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Literature summary for 1.14.13.8 extracted from

  • Reid, J.M.; Walker, D.L.; Miller, J.K.; Benson, L.M.; Tomlinson, A.J.; Naylor, S.; Blajeski, A.L.; LoRusso, P.M.; Ames, M.M.
    The metabolism of pyrazoloacridine (NSC 366140) by cytochromes P450 and flavin monooxygenase in human liver microsomes (2004), Clin. Cancer Res., 10, 1471-1480.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-naphthoflavone
-
 Homo sapiens
Methimazole
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.147
-
 pyrazoloacridine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyrazoloacridine + NADPH + O2
-
 Homo sapiens pyrazoloacridine N-oxide + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens