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Literature summary for 1.14.13.39 extracted from

  • Jin, B.Y.; Sartoretto, J.L.; Gladyshev, V.N.; Michel, T.
    Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells (2009), Proc. Natl. Acad. Sci. USA, 106, 17343-17348.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.39

Inhibitors

Inhibitors Comment Organism Structure
L-arginine methyl ester
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus eNOS is an important negative regulator of AMP-activated protein kinase phosphorylation and intracellular H2O2 generation in endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P70313
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
 Mus musculus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?
additional information eNOS is an important negative regulator of AMP-activated protein kinase phosphorylation and intracellular H2O2 generation in endothelial cells Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
endothelial nitric oxide synthase
-
 Mus musculus
eNOS
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
 Mus musculus
Calmodulin
-
 Mus musculus
NADPH
-
 Mus musculus

General Information

General Information Comment Organism
physiological function si-RNA mediated knockdown of eNOS leads to a striking increase in AMP-activated protein kinase phosphorylation, homozygot eNOS knockout mice show a marked increase in AMP-activated protein kinase phosphorylation in liver and lung compared to wild type mice Mus musculus