Literature summary for 1.14.13.39 extracted from

Tirapelli, C.R.; Fukada, S.Y.; Yogi, A.; Chignalia, A.Z.; Tostes, R.C.; Bonaventura, D.; Lanchote, V.L.; Cunha, F.Q.; de Oliveira, A.M.
Gender-specific vascular effects elicited by chronic ethanol consumption in rats: a role for inducible nitric oxide synthase (2008), Br. J. Pharmacol., 153, 468-479.

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Cloned(Commentary)

Cloned (Comment)	Organism
eNOS and iNOS expression analysis	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	ethanol intake reduces eNOS and increases iNOS protein levels, while mRNA levels remain unaffected in female rat aorta	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	increased iNOS expression due to ethanol intake is responsible for gender differences in the vascular effects elicited by chronic ethanol consumption, while ovarian hormones do not play a role, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	thoracic, muscle	Rattus norvegicus	-
skeletal muscle	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	increased iNOS expression due to ethanol intake is responsible for gender differences in the vascular effects elicited by chronic ethanol consumption, while ovarian hormones do not play a role, overview	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
endothelial NOS	-	Rattus norvegicus
eNOS	-	Rattus norvegicus
inducible nitric oxide synthase	-	Rattus norvegicus
inducible NO synthase	-	Rattus norvegicus
iNOS	-	Rattus norvegicus

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Release 2023.1 (January 2023)