Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | hepatic isozyme iNOS expression is induced in chronic liver cirrhosis early stages | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | Rattus norvegicus | - |
2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
additional information | Rattus norvegicus | NO is implicated in the pathogenesis of liver cirrhosis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q06518 | male Sprague-Dawley rats, isozyme iNOS | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
liver | temporal expression of hepatic iNOS in liver cirrhosis, induced in rats by chronic bile duct ligation, overview | Rattus norvegicus | - |
additional information | expression analysis in isolated hepatocytes, healthy liver, and cirrhotic liver, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Rattus norvegicus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
additional information | NO is implicated in the pathogenesis of liver cirrhosis, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inducible nitric oxide synthase | - |
Rattus norvegicus |
iNOS | - |
Rattus norvegicus |
nitric oxide synthase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |