Literature summary for 1.14.13.39 extracted from

Fish, J.E.; Matouk, C.C.; Rachlis, A.; Lin, S.; Tai, S.C.; DAbreo, C.; Marsden, P.A.
The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code (2005), J. Biol. Chem., 280, 24824-24838.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HUVE cells, vascular smooth muscle cells, and in HeLa cells, DNA methylation of proximal promoter sequences of eNOS promoter-beta-Gal fusion contructs in trangenic mice is not essential for cell-specific expression, endothelial cells are highly enriched in acetylated H3 and acetylated H4 at the eNOS promoter altering the promoter function and expression	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	genetic regulation, mechanism, eNOS expression is controlled by both histone acetylation and lysine 4 methylation of histone H3 at eNOS proximal promoter regions, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelium	specific isozyme eNOS	Homo sapiens	-
HUVEC cell	-	Homo sapiens	-
umbilical vein endothelium	i.e. HUVEC cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	genetic regulation, mechanism, eNOS expression is controlled by both histone acetylation and lysine 4 methylation of histone H3 at eNOS proximal promoter regions, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
endothelial nitric-oxide synthase	-	Homo sapiens
eNOS	-	Homo sapiens
NOS3	-	Homo sapiens

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Release 2023.1 (January 2023)