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Literature summary for 1.14.13.39 extracted from

  • Chen, K.; Popel, A.S.
    Vascular and perivascular nitric oxide release and transport: Biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3) (2007), Free Radic. Biol. Med., 42, 811-822.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.39

Activating Compound

Activating Compound Comment Organism Structure
Ca2+/calmodulin activate the electron transfer Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information biochemical pathway model, kinetic modeling, isozymes NOS1 and NOS3 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+/calmodulin activate the electron transfer Homo sapiens
O2 oxygen tension influences the activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Homo sapiens
-
 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes NOS1 and NOS3
-

Reaction

Reaction Comment Organism Reaction ID
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O reaction mechanism, NO release and transport, overview, NO formation through sequential electron transfer and the oxidation of L-arginine, in the catalytic process, FMN, FAD, and tetrahydrobiopterin are required as coenzymes, and the presence of Ca2+/calmodulin can aid the electron transfer, isozymes NOS1 and NOS3 perform a similar reaction mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
arteriole isozyme NOS3 Homo sapiens
-
mast cell isozyme NOS1 Homo sapiens
-
nerve isozyme NOS1 Homo sapiens
-
neuron isozyme NOS1 Homo sapiens
-
smooth muscle isozyme NOS3 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Homo sapiens 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Synonyms

Synonyms Comment Organism
endothelial nitric oxide synthase
-
 Homo sapiens
neuronal nitric oxide synthase
-
 Homo sapiens
NOS1
-
 Homo sapiens
NOS3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD required Homo sapiens
FMN required Homo sapiens
NADPH required Homo sapiens
tetrahydrobiopterin required Homo sapiens