Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,5,6,7-tetrahydro-2H-azepin-2-imines | - |
Rattus norvegicus | |
2-aminopyridine derivatives | highly selective inhibitors | Mus musculus | |
3,4-dihydro-1-isoquinolinamines | - |
Mus musculus | |
4-(3-amino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.0076 mM | Homo sapiens | |
4-(3-amino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.0119 mM | Mus musculus | |
4-(3-amino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.0091 mM | Rattus norvegicus | |
4-(3-amino-propoxy)-6-chloro-1H-quinolin-2-one trifluoroacetic acid salt | IC50: 410 nM, pharmacokinetic profile | Mus musculus | |
4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.004 mM | Homo sapiens | |
4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.01 mM | Mus musculus | |
4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.01 mM | Rattus norvegicus | |
4-(3-dimethylamino-propoxy)-1H-quinolin-2-one | IC50: 0.0026 mM | Homo sapiens | |
4-(3-dimethylamino-propoxy)-1H-quinolin-2-one | IC50: 0.0104 mM | Mus musculus | |
4-(3-dimethylamino-propoxy)-1H-quinolin-2-one | IC50: 0.010 mM | Rattus norvegicus | |
6-chloro-4-(3-aminopropoxy)-1-benzopyran-2-one trifluoroacetic acid salt | IC50: 90 nM, pharmacokinetic profile | Homo sapiens | |
6-chloro-4-(3-aminopropoxy)-1-benzopyran-2-one trifluoroacetic acid salt | IC50: 60 nM, pharmacokinetic profile | Mus musculus | |
6-chloro-4-(3-aminopropoxy)-1-benzopyran-2-one trifluoroacetic acid salt | IC50: 0.00056 mM, pharmacokinetic profile | Rattus norvegicus | |
6-chloro-4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.0041 mM | Homo sapiens | |
6-chloro-4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.0012 mM | Mus musculus | |
6-chloro-4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | IC50: 0.008 mM | Rattus norvegicus | |
6-chloro-4-(3-methylamino-propoxy)-1-benzopyran-2-one trifluoroacetic acid salt | IC50: 0.00011mM | Homo sapiens | |
6-chloro-4-(3-methylamino-propoxy)-1-benzopyran-2-one trifluoroacetic acid salt | IC50: 0.00025mM | Mus musculus | |
6-chloro-4-(3-methylamino-propoxy)-1-benzopyran-2-one trifluoroacetic acid salt | IC50: 0.00053mM | Rattus norvegicus | |
AR-C102222 | 1,2-dihydro-4-quinazolinamine derivative | Mus musculus | |
AR-C102222 | 1,2-dihydro-4-quinazolinamine derivative | Rattus norvegicus | |
AR-C85016 | 1,2-dihydro-4-quinazolinamine derivative | Mus musculus | |
AR-C85016 | 1,2-dihydro-4-quinazolinamine derivative | Rattus norvegicus | |
L-thiocitrulline | no isozyme specificity | Mus musculus | |
additional information | no inhibition by 4-(3-amino-propoxy)-6-chloro-1H-quinolin-2-one trifluoroacetic acid salt | Homo sapiens | |
additional information | inhibitory activity for coumarin derivatives, inhibitor screening, overview | Mus musculus | |
additional information | no inhibition by 4-(3-amino-propoxy)-6-chloro-1H-quinolin-2-one trifluoroacetic acid salt and thiocoumarin | Rattus norvegicus | |
N-iminoethyl-L-lysine | no isozyme specificity | Mus musculus | |
N-iminoethyl-L-ornithine | no isozyme specificity | Mus musculus | |
NG-methyl-L-arginine | no isozyme specificity | Mus musculus | |
NG-Nitro-L-arginine | no isozyme specificity | Mus musculus | |
thiocoumarin | IC50: 0.018 mM | Homo sapiens | |
thiocoumarin | weak inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | Homo sapiens | - |
2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | Rattus norvegicus | - |
2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | Mus musculus | - |
2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | P29477 | inducible enzyme | - |
Rattus norvegicus | - |
inducible enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Homo sapiens | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Rattus norvegicus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Mus musculus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nitric oxide synthase | - |
Homo sapiens |
nitric oxide synthase | - |
Rattus norvegicus |
nitric oxide synthase | - |
Mus musculus |
NOS | - |
Homo sapiens |
NOS | - |
Rattus norvegicus |
NOS | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
IC50: 60 nM, pharmacokinetic profile | Mus musculus | 6-chloro-4-(3-aminopropoxy)-1-benzopyran-2-one trifluoroacetic acid salt | |
0.00009 | - |
IC50: 90 nM, pharmacokinetic profile | Homo sapiens | 6-chloro-4-(3-aminopropoxy)-1-benzopyran-2-one trifluoroacetic acid salt | |
0.00011 | - |
IC50: 0.00011mM | Homo sapiens | 6-chloro-4-(3-methylamino-propoxy)-1-benzopyran-2-one trifluoroacetic acid salt | |
0.00025 | - |
IC50: 0.00025mM | Mus musculus | 6-chloro-4-(3-methylamino-propoxy)-1-benzopyran-2-one trifluoroacetic acid salt | |
0.00041 | - |
IC50: 410 nM, pharmacokinetic profile | Mus musculus | 4-(3-amino-propoxy)-6-chloro-1H-quinolin-2-one trifluoroacetic acid salt | |
0.00053 | - |
IC50: 0.00053mM | Rattus norvegicus | 6-chloro-4-(3-methylamino-propoxy)-1-benzopyran-2-one trifluoroacetic acid salt | |
0.00056 | - |
IC50: 0.00056 mM, pharmacokinetic profile | Rattus norvegicus | 6-chloro-4-(3-aminopropoxy)-1-benzopyran-2-one trifluoroacetic acid salt | |
0.0012 | - |
IC50: 0.0012 mM | Mus musculus | 6-chloro-4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.0026 | - |
IC50: 0.0026 mM | Homo sapiens | 4-(3-dimethylamino-propoxy)-1H-quinolin-2-one | |
0.004 | - |
IC50: 0.004 mM | Homo sapiens | 4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.0041 | - |
IC50: 0.0041 mM | Homo sapiens | 6-chloro-4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.0076 | - |
IC50: 0.0076 mM | Homo sapiens | 4-(3-amino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.008 | - |
IC50: 0.008 mM | Rattus norvegicus | 6-chloro-4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.0091 | - |
IC50: 0.0091 mM | Rattus norvegicus | 4-(3-amino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.01 | - |
IC50: 0.01 mM | Rattus norvegicus | 4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.01 | - |
IC50: 0.01 mM | Mus musculus | 4-(3-dimethylamino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.01 | - |
IC50: 0.010 mM | Rattus norvegicus | 4-(3-dimethylamino-propoxy)-1H-quinolin-2-one | |
0.0104 | - |
IC50: 0.0104 mM | Mus musculus | 4-(3-dimethylamino-propoxy)-1H-quinolin-2-one | |
0.0119 | - |
IC50: 0.0119 mM | Mus musculus | 4-(3-amino-propoxy)-1-benzopyran-2-one hydrochloric acid salt | |
0.018 | - |
IC50: 0.018 mM | Homo sapiens | thiocoumarin |