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Literature summary for 1.14.13.35 extracted from

  • Powlowski, J.; Ballou, D.P.; Massey, V.
    Studies of the oxidative half-reaction of anthranilate hydroxylase (deaminating) with native and modified substrates (1990), J. Biol. Chem., 265, 4969-4975.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Cutaneotrichosporon cutaneum
-
yeast
-

Reaction

Reaction Comment Organism Reaction ID
anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3 mechanism proposed involving imine formation and hydrolysis during the reaction with the flavin peroxide formed from reduced enzyme flavin and molecular oxygen Cutaneotrichosporon cutaneum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-thiobenzoate + NADPH + O2
-
Cutaneotrichosporon cutaneum ?
-
?
3-methylanthranilate + NADPH + O2
-
Cutaneotrichosporon cutaneum ? + NADP+ + NH3 the proposed structure of the product contains a ketone function at the position 2 ?
4-fluoroanthranilate + NADPH + O2
-
Cutaneotrichosporon cutaneum 4-fluoro-2,3-dihydroxybenzoate + NADP+ + NH3
-
?
5-fluoroanthranilate + NADPH + O2
-
Cutaneotrichosporon cutaneum 5-fluoro-2,3-dihydroxybenzoate + NADP+ + NH3
-
?
anthranilate + NADPH + O2
-
Cutaneotrichosporon cutaneum 2,3-dihydroxybenzoate + NADP+ + NH3
-
?

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Cutaneotrichosporon cutaneum
NADPH
-
Cutaneotrichosporon cutaneum