Application | Comment | Organism |
---|---|---|
medicine | albendazole as an anthelmintic drug is an important tool for the control of lancet fluke infections in small ruminants | Dicrocoelium dendriticum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
albendazole S-oxide | no formation of albendazole sulfone in the microsomal fraction in vitro, pH 7.4, 37°C | Dicrocoelium dendriticum | |
0.0015 | - |
albendazole S-oxide | mitochondrial fraction in vitro, pH 7.4, 37°C | Dicrocoelium dendriticum | |
0.0047 | - |
albendazole | microsomal fraction in vitro, pH 7.4, 37°C | Dicrocoelium dendriticum | |
0.0109 | - |
albendazole | mitochondrial fraction in vitro, pH 7.4, 37°C | Dicrocoelium dendriticum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Dicrocoelium dendriticum | - |
- |
mitochondrion | - |
Dicrocoelium dendriticum | 5739 | - |
additional information | no reaction in cytosol fraction | Dicrocoelium dendriticum | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 albendazole + 2 NADPH + 2 H+ + 2 O2 | Dicrocoelium dendriticum | - |
(+)-albendazole s-oxide + (-)-albendazole s-oxide + 2 NADP+ + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dicrocoelium dendriticum | - |
lancet fluke, isolated from naturally infected mouflon ewes (Ovis musimon) | - |
Purification (Comment) | Organism |
---|---|
Dicrocoelium dendriticum adults are washed and homogenized in 0.1 M sodium phosphate buffer, pH 7.4, with Potter-Elvehjem homogenizer and sonicator, ultracentrifugation separates mitochondrial fraction (resuspended in 0.1 M sodium phosphate buffer, pH 7.4) from microsome fraction (resuspended in the same buffer containing 20% glycerol), and cytosol fraction | Dicrocoelium dendriticum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0000237 | - |
microsomal fraction in vitro, pH 7.4, 37°C | Dicrocoelium dendriticum |
0.000052 | - |
mitochondrial fraction in vitro, pH 7.4, 37°C | Dicrocoelium dendriticum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 albendazole + 2 NADPH + 2 H+ + 2 O2 | - |
Dicrocoelium dendriticum | (+)-albendazole s-oxide + (-)-albendazole s-oxide + 2 NADP+ + 2 H2O | - |
? | |
2 albendazole + 2 NADPH + 2 H+ + 2 O2 | in vitro, 0.1 M sodium phosphate buffer, pH 7.4, 37°C, ex vivo, cultivation (48 h) of animals in phosphate buffered saline, pH 7.4, 38°C | Dicrocoelium dendriticum | (+)-albendazole s-oxide + (-)-albendazole s-oxide + 2 NADP+ + 2 H2O | - |
? | |
albendazole S-oxide + NADP+ + H2O | - |
Dicrocoelium dendriticum | albendazole + NADPH + H+ + O2 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
lancet fluke NADPH-dependent sulphoxidizing enzyme | - |
Dicrocoelium dendriticum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no metabolites are formed with NADH | Dicrocoelium dendriticum | |
NADPH | - |
Dicrocoelium dendriticum |