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Literature summary for 1.14.13.32 extracted from

  • Cvilink, V.; Szotakova, B.; Krizova, V.; Lamka, J.; Skalova, L.
    Phase I biotransformation of albendazole in lancet fluke (Dicrocoelium dendriticum) (2009), Res. Vet. Sci., 86, 49-55.
    View publication on PubMed

Application

Application Comment Organism
medicine albendazole as an anthelmintic drug is an important tool for the control of lancet fluke infections in small ruminants Dicrocoelium dendriticum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
albendazole S-oxide no formation of albendazole sulfone in the microsomal fraction in vitro, pH 7.4, 37°C Dicrocoelium dendriticum
0.0015
-
albendazole S-oxide mitochondrial fraction in vitro, pH 7.4, 37°C Dicrocoelium dendriticum
0.0047
-
albendazole microsomal fraction in vitro, pH 7.4, 37°C Dicrocoelium dendriticum
0.0109
-
albendazole mitochondrial fraction in vitro, pH 7.4, 37°C Dicrocoelium dendriticum

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Dicrocoelium dendriticum
-
-
mitochondrion
-
Dicrocoelium dendriticum 5739
-
additional information no reaction in cytosol fraction Dicrocoelium dendriticum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 albendazole + 2 NADPH + 2 H+ + 2 O2 Dicrocoelium dendriticum
-
(+)-albendazole s-oxide + (-)-albendazole s-oxide + 2 NADP+ + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Dicrocoelium dendriticum
-
lancet fluke, isolated from naturally infected mouflon ewes (Ovis musimon)
-

Purification (Commentary)

Purification (Comment) Organism
Dicrocoelium dendriticum adults are washed and homogenized in 0.1 M sodium phosphate buffer, pH 7.4, with Potter-Elvehjem homogenizer and sonicator, ultracentrifugation separates mitochondrial fraction (resuspended in 0.1 M sodium phosphate buffer, pH 7.4) from microsome fraction (resuspended in the same buffer containing 20% glycerol), and cytosol fraction Dicrocoelium dendriticum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000237
-
microsomal fraction in vitro, pH 7.4, 37°C Dicrocoelium dendriticum
0.000052
-
mitochondrial fraction in vitro, pH 7.4, 37°C Dicrocoelium dendriticum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 albendazole + 2 NADPH + 2 H+ + 2 O2
-
Dicrocoelium dendriticum (+)-albendazole s-oxide + (-)-albendazole s-oxide + 2 NADP+ + 2 H2O
-
?
2 albendazole + 2 NADPH + 2 H+ + 2 O2 in vitro, 0.1 M sodium phosphate buffer, pH 7.4, 37°C, ex vivo, cultivation (48 h) of animals in phosphate buffered saline, pH 7.4, 38°C Dicrocoelium dendriticum (+)-albendazole s-oxide + (-)-albendazole s-oxide + 2 NADP+ + 2 H2O
-
?
albendazole S-oxide + NADP+ + H2O
-
Dicrocoelium dendriticum albendazole + NADPH + H+ + O2
-
r

Synonyms

Synonyms Comment Organism
lancet fluke NADPH-dependent sulphoxidizing enzyme
-
Dicrocoelium dendriticum

Cofactor

Cofactor Comment Organism Structure
additional information no metabolites are formed with NADH Dicrocoelium dendriticum
NADPH
-
Dicrocoelium dendriticum