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Literature summary for 1.14.13.25 extracted from

  • Murrell, J.C.; Gilbert, B.; McDonald, I.R.
    Molecular biology and regulation of methane monooxygenase (2000), Arch. Microbiol., 173, 325-332.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Methylococcus capsulatus
expressed in Escherichia coli Methylomicrobium album
expressed in Escherichia coli Methylocystis sp.

Inhibitors

Inhibitors Comment Organism Structure
Cu2+ copper ions irreversibly inhibit the activity of sMMO in vivo and in vitro by inactivating the reductase component Methylococcus capsulatus
Cu2+ copper ions irreversibly inhibit the activity of sMMO in vivo and in vitro by inactivating the reductase component Methylocystis sp.
Cu2+ copper ions irreversibly inhibit the activity of sMMO in vivo and in vitro by inactivating the reductase component Methylomicrobium album

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Methylococcus capsulatus 5737
-
cytoplasm
-
Methylomicrobium album 5737
-
cytoplasm
-
Methylocystis sp. 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methane + duroquinol + O2 Methylococcus capsulatus
-
methanol + duroquinone + H2O
-
?
methane + duroquinol + O2 Methylomicrobium album
-
methanol + duroquinone + H2O
-
?
methane + duroquinol + O2 Methylocystis sp.
-
methanol + duroquinone + H2O
-
?
methane + duroquinol + O2 Methylococcus capsulatus Bath
-
methanol + duroquinone + H2O
-
?
methane + duroquinol + O2 Methylomicrobium album BG8
-
methanol + duroquinone + H2O
-
?
methane + reduced acceptor + H* + O2 Methylococcus capsulatus
-
methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2 Methylomicrobium album
-
methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2 Methylocystis sp.
-
methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2 Methylococcus capsulatus Bath
-
methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2 Methylomicrobium album BG8
-
methanol + acceptor + H2O
-
?
additional information Methylococcus capsulatus the sMMO enzyme has broad substrate specificity compared to pMMO ?
-
?
additional information Methylomicrobium album the sMMO enzyme has broad substrate specificity compared to pMMO ?
-
?
additional information Methylocystis sp. the sMMO enzyme has broad substrate specificity compared to pMMO ?
-
?
additional information Methylococcus capsulatus Bath the sMMO enzyme has broad substrate specificity compared to pMMO ?
-
?
additional information Methylomicrobium album BG8 the sMMO enzyme has broad substrate specificity compared to pMMO ?
-
?

Organism

Organism UniProt Comment Textmining
Methylococcus capsulatus
-
-
-
Methylococcus capsulatus Bath
-
-
-
Methylocystis sp.
-
-
-
Methylomicrobium album
-
-
-
Methylomicrobium album BG8
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methane + duroquinol + O2
-
Methylococcus capsulatus methanol + duroquinone + H2O
-
?
methane + duroquinol + O2
-
Methylomicrobium album methanol + duroquinone + H2O
-
?
methane + duroquinol + O2
-
Methylocystis sp. methanol + duroquinone + H2O
-
?
methane + duroquinol + O2
-
Methylococcus capsulatus Bath methanol + duroquinone + H2O
-
?
methane + duroquinol + O2
-
Methylomicrobium album BG8 methanol + duroquinone + H2O
-
?
methane + reduced acceptor + H* + O2
-
Methylococcus capsulatus methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2
-
Methylomicrobium album methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2
-
Methylocystis sp. methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2
-
Methylococcus capsulatus Bath methanol + acceptor + H2O
-
?
methane + reduced acceptor + H* + O2
-
Methylomicrobium album BG8 methanol + acceptor + H2O
-
?
additional information the sMMO enzyme has broad substrate specificity compared to pMMO Methylococcus capsulatus ?
-
?
additional information the sMMO enzyme has broad substrate specificity compared to pMMO Methylomicrobium album ?
-
?
additional information the sMMO enzyme has broad substrate specificity compared to pMMO Methylocystis sp. ?
-
?
additional information the sMMO enzyme has broad substrate specificity compared to pMMO Methylococcus capsulatus Bath ?
-
?
additional information the sMMO enzyme has broad substrate specificity compared to pMMO Methylomicrobium album BG8 ?
-
?

Synonyms

Synonyms Comment Organism
sMMO
-
Methylococcus capsulatus
sMMO
-
Methylomicrobium album
sMMO
-
Methylocystis sp.
soluble methane monooxygenase
-
Methylococcus capsulatus
soluble methane monooxygenase
-
Methylomicrobium album
soluble methane monooxygenase
-
Methylocystis sp.

Expression

Organism Comment Expression
Methylococcus capsulatus transcription of sMMO is arrested in cells exposed to high levels of copper ions and sMMO mRNA transcripts are not detected 15 min after the addition of CuSO4 down
Methylomicrobium album transcription of sMMO is arrested in cells exposed to high levels of copper ions and sMMO mRNA transcripts are not detected 15 min after the addition of CuSO4 down
Methylocystis sp. transcription of sMMO is arrested in cells exposed to high levels of copper ions and sMMO mRNA transcripts are not detected 15 min after the addition of CuSO4 down
Methylococcus capsulatus the sMMO enzyme is expressed when cells are essentially starved for copper and the copper-to-biomass ratio is low (less than 0.0002 mM Cu2+) up
Methylomicrobium album the sMMO enzyme is expressed when cells are essentially starved for copper and the copper-to-biomass ratio is low (less than 0.0002 mM Cu2+) up
Methylocystis sp. the sMMO enzyme is expressed when cells are essentially starved for copper and the copper-to-biomass ratio is low (less than 0.0002 mM Cu2+) up