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Literature summary for 1.14.13.246 extracted from

  • Lee, A.; Banta, A.; Wei, J.; Kiemle, D.; Feng, J.; Giner, J.; Welander, P.
    C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis (2018), Proc. Natl. Acad. Sci. USA, 115, 5884-5889 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.13.246

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 H+ + 3 O2 Methylococcus capsulatus
-
 a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD+ + 4 H2O
-
 ?
a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 H+ + 3 O2 Methylococcus capsulatus Texas H156DRAFT2756-2755
-
 a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD+ + 4 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Methylococcus capsulatus
-
-
-
Methylococcus capsulatus Texas H156DRAFT2756-2755
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4beta-28-hydroxylanosterol + NADH + H+ + O2
-
 Methylococcus capsulatus 4beta-28-oxolanosterol + NAD+ + 2 H2O
-
 ?
4beta-28-hydroxylanosterol + NADH + H+ + O2
-
 Methylococcus capsulatus Texas H156DRAFT2756-2755 4beta-28-oxolanosterol + NAD+ + 2 H2O
-
 ?
4beta-28-oxolanosterol + NADH + H+ + O2
-
 Methylococcus capsulatus 4beta3beta-hydroxylanosta-8,24-dien-28-oic acid + NAD+ + H2O
-
 ?
4beta-28-oxolanosterol + NADH + H+ + O2
-
 Methylococcus capsulatus Texas H156DRAFT2756-2755 4beta3beta-hydroxylanosta-8,24-dien-28-oic acid + NAD+ + H2O
-
 ?
a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 H+ + 3 O2
-
 Methylococcus capsulatus a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD+ + 4 H2O
-
 ?
a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 H+ + 3 O2
-
 Methylococcus capsulatus Texas H156DRAFT2756-2755 a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD+ + 4 H2O
-
 ?
lanosterol + NADH + H+ + O2
-
 Methylococcus capsulatus 4beta-28-hydroxylanosterol + 4alpha-28-hydroxylanosterol + NAD+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
SdmA
-
 Methylococcus capsulatus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Methylococcus capsulatus

General Information

General Information Comment Organism
metabolism the enzyme participates in sterol C-4 demethylation Methylococcus capsulatus