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Literature summary for 1.14.13.180 extracted from
- Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products (2002), FEMS Microbiol. Lett., 208, 117-122.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aklavinone + NADPH + H+ + O2 | Streptomyces purpurascens | the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway. During the biosynthesis of L-rhodomycins, RdmE first modifies aklavinone at C-11, and epsilon-rhodomycinone or aklavinone is subsequently glycosylated | epsilon-rhodomycinone + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces purpurascens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces purpurascens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11-deoxy-beta-L-rhodomycinone + NADPH + H+ + O2 | 11-deoxy-L-rhodomycinone is a better substrate than aklavinone | Streptomyces purpurascens | beta-rhodomycinone + NADP+ + H2O | - |
? | |
| aklavinone + NADPH + H+ + O2 | the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway. During the biosynthesis of L-rhodomycins, RdmE first modifies aklavinone at C-11, and epsilon-rhodomycinone or aklavinone is subsequently glycosylated | Streptomyces purpurascens | epsilon-rhodomycinone + NADP+ + H2O | - |
? | |
| aklavinone + NADPH + H+ + O2 | about 60% compared to the activity with 11-deoxy-L-rhodomycinone | Streptomyces purpurascens | epsilon-rhodomycinone + NADP+ + H2O | - |
? | |
| additional information | no activity with decarbomethoxyaklavinone or 15-demethoxyaklavinone | Streptomyces purpurascens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RdmE | - |
Streptomyces purpurascens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway | Streptomyces purpurascens |
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