BRENDA - Enzyme Database
show all sequences of 1.14.13.178

Characterization of human liver cytochromes P-450 involved in theophylline metabolism

Sarkar, M.; Hunt, C.; Guzelian, P.; Karnes, H.; Drug Metab. Dispos. 20, 31-37 (1992)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
theophylline + O2 + NADPH + H+
Homo sapiens
i.e. 1,3-dimethylxanthine
3-methylxanthine + NADP+ + H2O + formaldehyde
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
theophylline + O2 + NADPH + H+
i.e. 1,3-dimethylxanthine
724824
Homo sapiens
3-methylxanthine + NADP+ + H2O + formaldehyde
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
P450-d
-
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
required
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
required
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
theophylline + O2 + NADPH + H+
Homo sapiens
i.e. 1,3-dimethylxanthine
3-methylxanthine + NADP+ + H2O + formaldehyde
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
theophylline + O2 + NADPH + H+
i.e. 1,3-dimethylxanthine
724824
Homo sapiens
3-methylxanthine + NADP+ + H2O + formaldehyde
-
-
-
?
Other publictions for EC 1.14.13.178
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
722538
Summers
Novel, highly specific N-demet ...
Pseudomonas putida, Pseudomonas putida CBB5
J. Bacteriol.
194
2041-2049
2012
-
-
1
-
-
-
-
4
-
1
2
5
-
4
-
-
1
-
-
-
-
-
13
1
1
1
-
-
4
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
4
-
1
2
5
-
-
-
1
-
-
-
-
13
1
1
-
-
4
1
-
-
-
-
1
1
-
4
4
709854
Summers
Characterization of a broad-sp ...
Pseudomonas putida, Pseudomonas putida CBB5
Microbiology
157
583-592
2011
-
-
-
-
-
-
-
-
-
1
-
-
-
4
-
-
1
3
-
-
-
-
6
1
1
1
-
-
-
1
-
-
2
-
-
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-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
6
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
724824
Sarkar
Characterization of human live ...
Homo sapiens
Drug Metab. Dispos.
20
31-37
1992
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
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1
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1
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1
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-
1
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-
-
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1
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1
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-
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1
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1
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