Genome mining in Streptomyces avermitilis: A biochemical Baeyer-Villiger reaction and discovery of a new branch of the pentalenolactone family tree

Jiang, J.; Tetzlaff, C.N.; Takamatsu, S.; Iwatsuki, M.; Komatsu, M.; Ikeda, H.; Cane, D.E.; Biochemistry 48, 6431-6440 (2009)

Data extracted from this reference:

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

1-deoxy-11-oxopentalenate + NADPH + H+ + O2

-

718853

Streptomyces avermitilis

neopentalenolactone D + NADP+ + H2O

-

-

-

?

Cofactor

Commentary

Organism

Structure

FAD

-

Streptomyces avermitilis

NADPH

-

Streptomyces avermitilis

Cofactor

Commentary

Organism

Structure

FAD

-

Streptomyces avermitilis

NADPH

-

Streptomyces avermitilis

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

1-deoxy-11-oxopentalenate + NADPH + H+ + O2

-

718853

Streptomyces avermitilis

neopentalenolactone D + NADP+ + H2O

-

-

-

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Protein Variants

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

kcat/KM [mM/s]

kcat/KM [mM/s] (protein specific)

718892

Seo

Genome mining in Streptomyces. ...

Streptomyces arenae, Streptomyces avermitilis, Streptomyces exfoliatus, Streptomyces exfoliatus UC5319, Streptomyces arenae TUE469

Biochemistry

50

1739-1754

2011

-

-

-

-

-

-

-

-

-

-

-

-

-

10

-

-

-

-

-

-

-

-

6

-

3

-

-

-

-

-

-

-

3

-

-

-

-

-

-

3

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

6

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

718853

Jiang

Genome mining in Streptomyces ...

Streptomyces avermitilis

Biochemistry

48

6431-6440

2009

-

-

1

-

-

-

-

-

-

-

2

-

-

1

-

-

1

-

-

-

-

-

1

2

1

-

-

-

-

-

-

-

2

-

-

-

-

-

1

2

-

-

-

-

-

-

-

-

-

2

-

-

-

-

1

-

-

-

-

1

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-