Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Homo sapiens |
expressed in Sf9 insect cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Thiourea | - |
Homo sapiens | |
Thiourea | thiourea reduces ethionamide oxygenation to ethionamide S-oxide by an average of 73.5% in liver and 76.9% in lung | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.114 | - |
Ethionamide | isozyme FMO3, at pH 9.5 and 37°C | Mus musculus | |
0.336 | - |
Ethionamide | isozyme FMO3, at pH 9.5 and 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31513 | - |
- |
Mus musculus | P97501 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | FMO3 is the major hepatic isozyme in adults | Homo sapiens | - |
lung | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ethionamide + NADPH + H+ + O2 | - |
Homo sapiens | ethionamide S-oxide + NADP+ + H2O | - |
? | |
ethionamide + NADPH + H+ + O2 | - |
Mus musculus | ethionamide S-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flavin-containing monooxygenase | - |
Homo sapiens |
flavin-containing monooxygenase | - |
Mus musculus |
FMO3 | isozyme | Homo sapiens |
FMO3 | isozyme | Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.973 | - |
Ethionamide | isozyme FMO3, at pH 9.5 and 37°C | Homo sapiens | |
1.01 | - |
Ethionamide | isozyme FMO3, at pH 9.5 and 37°C | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Mus musculus | |
NADPH | required for activity | Homo sapiens | |
NADPH | required for activity | Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | isoform FMO3 in human liver may contribute to the toxicity and/or affect efficacy of ethionamide administration | Homo sapiens |