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Literature summary for 1.14.12.19 extracted from

  • Chalabaev, S.; Turlin, E.; Bay, S.; Ganneau, C.; Brito-Fravallo, E.; Charles, J.F.; Danchin, A.; Biville, F.
    Cinnamic acid, an autoinducer of its own biosynthesis, is processed via Hca enzymes in Photorhabdus luminescens (2008), Appl. Environ. Microbiol., 74, 1717-1725.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.12.19

Activating Compound

Activating Compound Comment Organism Structure
Cinnamic acid induces the expression of the hca operon, the plu2201 and plu2202 genes, and stlA expression Photorhabdus luminescens

Organism

Organism UniProt Comment Textmining
Photorhabdus luminescens
-
 TT01R strains
-
Photorhabdus luminescens TT01R
-
 TT01R strains
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phenylpropionate + NADH + H+ + O2
-
 Photorhabdus luminescens 3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dien-1-yl]propanoic acid + NAD+
-
 ?
3-phenylpropionate + NADH + H+ + O2
-
 Photorhabdus luminescens TT01R 3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dien-1-yl]propanoic acid + NAD+
-
 ?
cinnamic acid + NADH + H+ + O2 HcaE is involved in degradation of endogenous cinnamic acid Photorhabdus luminescens cinnamic acid-2,3-dihydrodiol + NAD+
-
 ?
cinnamic acid + NADH + H+ + O2 HcaE is involved in degradation of endogenous cinnamic acid Photorhabdus luminescens TT01R cinnamic acid-2,3-dihydrodiol + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
Hca dioxygenase
-
 Photorhabdus luminescens

General Information

General Information Comment Organism
physiological function Hca dioxygenase is involved in the consumption of endogenous cinnamic acid but is not required for 3,5-dihydroxy-4-isopropylstilbene antibiotic production. Disruption of hcaE abolishes the stationary-phase-dependent decrease of extracellular cinnamic acid evidenced in the wild-type strain, hcaE disruption increases stlA expression, thus enhancing cinnamic acid synthesis. Effect of cinnamic acid on plu2201 and plu2202 expression requires HcaR, whereas HcaR is not required for cinnamic acid-induced stlA expression Photorhabdus luminescens