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Literature summary for 1.14.12.17 extracted from
- Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology (2011), Biotechniques, 50, 41-45.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | heterologous expression of Escherichia coli flavohemoglobin within a lentiviral delivery system boosts endogenous cellular consumption of NO, thus providing a simple and efficacious approach to studying mammalian NO-biology | Escherichia coli |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| heterologous expression within a lentiviral delivery system | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | heterologous expression within a lentiviral delivery system results in markedly increased NADPH consumption, which is dependent on the addition of exogenous NO. Expression does not exhibit any noticeable toxicity or growth suppression in several tested mammalian cell types. Flavohemoglobin metabolizes endogenously synthesized NO to NO3- in mammalian cells without affecting NO synthesis itself | Escherichia coli |
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Release 2023.1 (January 2023)
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