Literature summary for 1.14.12.12 extracted from

Ohta, T.; Chakrabarty, S.; Lipscomb, J.D.; Solomon, E.I.
Near-IR MCD of the nonheme ferrous active site in naphthalene 1,2-dioxygenase: correlation to crystallography and structural insight into the mechanism of Rieske dioxygenases (2008), J. Am. Chem. Soc., 130, 1601-1610.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	the catalytic ferrous site is primed for the O2 reaction when substrate is bound in the active site in the presence of the reduced Rieske site. These structural changes ensure that two electrons and the substrate are present before the binding and activation of O2, which avoids the uncontrolled formation and release of reactive oxygen species	Pseudomonas sp.

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas sp.	-	NCIB 9816-4	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
naphthalene + NADH + H+ + O2	the catalytic ferrous site is primed for the O2 reaction when substrate is bound in the active site in the presence of the reduced Rieske site. These structural changes ensure that two electrons and the substrate are present before the binding and activation of O2, which avoids the uncontrolled formation and release of reactive oxygen species	Pseudomonas sp.	(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+	-	?

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Release 2023.1 (January 2023)