BRENDA - Enzyme Database show
show all sequences of 1.14.11.B2

Identification of non-histone substrates for JMJD2A-C histone demethylases

Ponnaluri, V.; Vavilala, D.; Putty, S.; Gutheil, W.; Mukherji, M.; Biochem. Biophys. Res. Commun. 390, 280-284 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
JMJD2A-C genes, DNA and amino acid sequence determination and analysis, expression of the GST-tagged isozymes JMJD2A, JMJD2B, and JMJD2C in Escherichia coli strain BL21(DE3)
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
isozymes JMJD2A, JMJD2B, and JMJD2C
-
Purification (Commentary)
Commentary
Organism
recombinant GST-tagged isozymes JMJD2A, JMJD2B, and JMJD2C from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography
Homo sapiens
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
specific isozyme activities with non-histone substrates, overview
Homo sapiens
0.00029
-
recombinant purified isozyme JMJD2B, substrate histone H3K9
Homo sapiens
0.0005
-
recombinant purified isozyme JMJD2C, substrate histone H3K9
Homo sapiens
0.001
-
recombinant purified isozyme JMJD2A, substrate histone H3K9
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
substrate specificity of recombinant isozymes, overview
696057
Homo sapiens
?
-
-
-
-
[chromodomain Y-like protein]-N6,N6,N6-trimethyl-L-lysine135 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine1054 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine170 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine297 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine448 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[G9a protein]-N6,N6,N6-trimethyl-L-lysine185 + 2-oxoglutarate + O2
a customer synthesized protein
696057
Homo sapiens
?
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
696057
Homo sapiens
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
isozyme JMJD2A substrate binding structure, overview
696057
Homo sapiens
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
[widely interspaced zinc finger motifs protein]-N6,N6,N6-trimethyl-L-lysine305 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
JMJD2A-C genes, DNA and amino acid sequence determination and analysis, expression of the GST-tagged isozymes JMJD2A, JMJD2B, and JMJD2C in Escherichia coli strain BL21(DE3)
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
Homo sapiens
-
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant GST-tagged isozymes JMJD2A, JMJD2B, and JMJD2C from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography
Homo sapiens
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
specific isozyme activities with non-histone substrates, overview
Homo sapiens
0.00029
-
recombinant purified isozyme JMJD2B, substrate histone H3K9
Homo sapiens
0.0005
-
recombinant purified isozyme JMJD2C, substrate histone H3K9
Homo sapiens
0.001
-
recombinant purified isozyme JMJD2A, substrate histone H3K9
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
substrate specificity of recombinant isozymes, overview
696057
Homo sapiens
?
-
-
-
-
[chromodomain Y-like protein]-N6,N6,N6-trimethyl-L-lysine135 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine1054 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine170 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine297 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[Cockayne syndrome group B protein]-N6,N6,N6-trimethyl-L-lysine448 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
[G9a protein]-N6,N6,N6-trimethyl-L-lysine185 + 2-oxoglutarate + O2
a customer synthesized protein
696057
Homo sapiens
?
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
696057
Homo sapiens
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
isozyme JMJD2A substrate binding structure, overview
696057
Homo sapiens
[histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
-
-
?
[widely interspaced zinc finger motifs protein]-N6,N6,N6-trimethyl-L-lysine305 + 2-oxoglutarate + O2
-
696057
Homo sapiens
?
-
-
-
?
Other publictions for EC 1.14.11.B2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Homo sapiens
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2617-2624
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-
-
-
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-
-
1
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1
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1
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1
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13
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1
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15
13
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1
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1
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1
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-
744646
Tumber
Potent and selective KDM5 inh ...
Homo sapiens
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24
371-380
2017
-
-
-
1
-
-
6
-
1
1
-
10
-
4
-
-
-
-
-
3
-
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12
-
-
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-
-
-
-
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8
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1
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9
10
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4
4
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10
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12
-
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12
-
-
-
-
-
-
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1
4
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744866
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Mus musculus
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32
552-567
2017
-
-
1
-
4
-
-
-
1
1
-
2
-
2
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1
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2
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4
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1
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1
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2
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-
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2
2
-
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745752
Liu
LincRNAFEZF1-AS1 represses p2 ...
Homo sapiens
Mol. Cancer
16
39
2017
-
-
-
-
-
-
-
-
1
1
-
3
-
1
-
-
-
-
-
3
-
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3
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1
1
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3
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3
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745771
Vyas
Lysine-specific demethylase-1 ...
Mus musculus
Mol. Cell. Neurosci.
82
1-11
2017
-
-
1
-
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
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3
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1
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1
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2
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1
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3
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744347
Burg
Lysine-specific demethylase 1 ...
Homo sapiens
Biochemistry
55
1652-1662
2016
-
-
-
-
-
-
3
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
6
1
1
-
-
-
1
-
-
1
3
-
1
-
-
-
1
-
-
-
1
3
3
-
-
-
-
3
-
-
-
-
-
-
-
-
6
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
744653
Zhao
H3K4me3 demethylase Kdm5a is ...
Mus musculus
Cell Rep.
15
288-299
2016
-
-
-
-
-
-
-
-
2
1
-
2
-
3
-
-
-
-
-
2
-
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2
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2
1
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2
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2
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744762
Mariani
The H3K4me3/2 histone demethy ...
Caenorhabditis elegans
Development
143
851-863
2016
-
-
1
-
1
-
1
-
1
-
-
1
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
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-
-
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1
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1
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1
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1
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1
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-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
745354
Horton
Characterization of a linked ...
Homo sapiens
J. Biol. Chem.
291
2631-2646
2016
-
-
1
-
1
-
3
1
-
1
-
6
-
3
-
-
1
-
-
-
-
-
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
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9
-
2
-
3
-
6
-
-
-
3
-
-
-
-
9
3
-
-
-
-
-
-
-
-
-
4
11
-
-
-
745525
Bavetsias
8-Substituted pyrido[3,4-d]py ...
Homo sapiens
J. Med. Chem.
59
1388-1409
2016
-
-
-
-
1
-
66
-
1
1
-
5
-
2
-
-
-
-
-
2
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
127
-
-
2
2
-
5
-
-
-
-
-
4
-
-
5
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
745804
Popova
LSD1-mediated demethylation o ...
Mus musculus
Mol. Neurobiol.
53
4563-4581
2016
-
-
1
-
-
-
2
-
1
1
-
3
-
2
-
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-
3
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4
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1
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2
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1
1
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3
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3
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4
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
746464
Soloveychik
Mitochondrial control through ...
Saccharomyces cerevisiae
Sci. Rep.
6
37942
2016
-
-
-
-
1
-
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-
2
1
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1
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2
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1
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1
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2
1
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1
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1
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-
-
-
-
-
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-
4
4
-
-
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746537
Xiao
Cadmium induces histone H3 ly ...
Homo sapiens
Toxicol. Sci.
145
80-89
2015
1
-
-
-
-
-
1
-
2
1
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1
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2
-
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1
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1
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1
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1
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1
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1
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2
1
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1
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1
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1
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1
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1
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-
-
-
-
-
-
-
-
744188
El Mansouri
Lysine-specific demethylase 1 ...
Homo sapiens
Arthritis Res. Ther.
16
R113
2014
1
-
1
-
1
-
2
-
1
1
-
2
-
1
-
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1
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2
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1
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1
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1
1
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1
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2
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1
1
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2
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1
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2
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-
-
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-
-
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3
3
-
-
-
744589
Ryu
Yeast histone H3 lysine 4 dem ...
Saccharomyces cerevisiae
BMC Biol.
12
75
2014
-
-
1
-
2
-
-
-
-
1
-
1
-
1
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2
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-
2
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-
-
-
-
-
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4
4
-
-
-
744657
Klein
The histone-H3K4-specific dem ...
Homo sapiens
Cell Rep.
6
325-335
2014
-
-
1
-
3
-
-
-
2
-
-
4
-
1
-
-
-
-
-
14
-
-
4
-
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-
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1
-
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3
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2
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4
-
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-
-
14
-
-
4
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
744990
Shen
Over-expression of histone H3 ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Front. Plant Sci.
5
290
2014
-
-
1
-
1
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1
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2
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4
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2
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6
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1
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1
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1
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2
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2
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6
-
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-
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2
2
-
-
-
745309
Nishibuchi
Physical and functional inter ...
Caenorhabditis elegans, Homo sapiens
J. Biol. Chem.
289
28956-28970
2014
-
-
2
-
1
-
-
-
4
2
1
6
-
3
-
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1
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2
-
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8
-
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2
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1
-
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-
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4
2
1
6
-
-
-
1
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2
-
-
8
-
-
-
-
-
-
-
-
-
-
6
6
-
-
-
746266
Yokoo
Se14, encoding a JmjC domain- ...
Oryza sativa Japonica Group
PLoS ONE
9
e96064
2014
-
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LSD1 demethylates histone and ...
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Cui
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