BRENDA - Enzyme Database show
show all sequences of 1.14.11.B2

Chromatin remodeling demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation

Yu, X.; Chen, H.; Zuo, C.; Jin, X.; Yin, Y.; Wang, H.; Jin, M.; Ozato, K.; Xu, S.; FASEB J. 32, 552-567 (2017)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene KDM5A, recombinant coexpression of wild-type and mutant FLAG-tagged Piasy and HA-tagged Rbp2 from pcDNA3.1(+) HA expression vector and p33 Flag CMV7.1 expression vector, respectively, in HEK-293T cells
Mus musculus
Engineering
Amino acid exchange
Commentary
Organism
H483G/E485Q
site-directed mutagenesis
Mus musculus
K152A
site-directed mutagenesis
Mus musculus
K152E
site-directed mutagenesis
Mus musculus
additional information
RBP2 enzyme knockout by transfection of siRNA, that targets Rbp2, into Piasy+/+ MEFs
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
chromatin
-
Mus musculus
785
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
required for catalysis
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
-
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
additional information
Mus musculus
protein-protein interaction anaysis of wild-type and mutants and interactional domains between Rbp2 and Piasy, overview
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
Q3UXZ9
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
fibroblast
mouse embryonic fibroblasts, MEFs
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
744866
Mus musculus
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
additional information
protein-protein interaction anaysis of wild-type and mutants and interactional domains between Rbp2 and Piasy, overview
744866
Mus musculus
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
gene KDM5A, recombinant coexpression of wild-type and mutant FLAG-tagged Piasy and HA-tagged Rbp2 from pcDNA3.1(+) HA expression vector and p33 Flag CMV7.1 expression vector, respectively, in HEK-293T cells
Mus musculus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H483G/E485Q
site-directed mutagenesis
Mus musculus
K152A
site-directed mutagenesis
Mus musculus
K152E
site-directed mutagenesis
Mus musculus
additional information
RBP2 enzyme knockout by transfection of siRNA, that targets Rbp2, into Piasy+/+ MEFs
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
chromatin
-
Mus musculus
785
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
required for catalysis
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
Mus musculus
-
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
-
?
additional information
Mus musculus
protein-protein interaction anaysis of wild-type and mutants and interactional domains between Rbp2 and Piasy, overview
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
fibroblast
mouse embryonic fibroblasts, MEFs
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
744866
Mus musculus
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
-
-
?
additional information
protein-protein interaction anaysis of wild-type and mutants and interactional domains between Rbp2 and Piasy, overview
744866
Mus musculus
?
-
-
-
-
General Information
General Information
Commentary
Organism
malfunction
overexpression of Rbp2, but not its enzymatically inactive mutant Rbp2H483G/E485Q, retards the transcription activities of IFNI, whereas small interfering RNA-mediated or short hairpin RNA-mediated knockdown of Rbp2 enhances IFNI promoter responses
Mus musculus
physiological function
retinoblastoma binding protein 2 (Rbp2) is a H3K4me3 demethylase that interacts with Piasy, a Pias (protein inhibitor of activated signal transducer and activator of transcription) family member, which possesses the ability to suppress IFNI transcriptions in mouse embryonic fibroblasts (MEFs). The H3K4me3 levels, one activation mark of genes, in MEFsthat are stimulated by poly(I:C), are impaired by Piasy in the IFN-beta gene. Piasy binds to the Jmjc domain (residues 451-503) of Rbp2 via its PINIT domain (residues 101-218), which is consistent with the domain required for their attenuation of transcription and H3K4me3 levels of IFNI genes. Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses. Piasy reduces H3K4me3 levels of IFNI genes upon activation in MEFs, the Jmjc domain of Rbp2 and the PINIT domain of Piasy are prerequisites. Demethylase activity of Rbp2, but not DNA contact by K152, is indispensable
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
overexpression of Rbp2, but not its enzymatically inactive mutant Rbp2H483G/E485Q, retards the transcription activities of IFNI, whereas small interfering RNA-mediated or short hairpin RNA-mediated knockdown of Rbp2 enhances IFNI promoter responses
Mus musculus
physiological function
retinoblastoma binding protein 2 (Rbp2) is a H3K4me3 demethylase that interacts with Piasy, a Pias (protein inhibitor of activated signal transducer and activator of transcription) family member, which possesses the ability to suppress IFNI transcriptions in mouse embryonic fibroblasts (MEFs). The H3K4me3 levels, one activation mark of genes, in MEFsthat are stimulated by poly(I:C), are impaired by Piasy in the IFN-beta gene. Piasy binds to the Jmjc domain (residues 451-503) of Rbp2 via its PINIT domain (residues 101-218), which is consistent with the domain required for their attenuation of transcription and H3K4me3 levels of IFNI genes. Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses. Piasy reduces H3K4me3 levels of IFNI genes upon activation in MEFs, the Jmjc domain of Rbp2 and the PINIT domain of Piasy are prerequisites. Demethylase activity of Rbp2, but not DNA contact by K152, is indispensable
Mus musculus
Other publictions for EC 1.14.11.B2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744494
Amano
Development and crystallograp ...
Homo sapiens
Bioorg. Med. Chem.
25
2617-2624
2017
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13
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744646
Tumber
Potent and selective KDM5 inh ...
Homo sapiens
Cell Chem. Biol.
24
371-380
2017
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1
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6
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1
1
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10
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10
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4
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12
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12
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1
4
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744866
Yu
Chromatin remodeling demethyl ...
Mus musculus
FASEB J.
32
552-567
2017
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1
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4
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2
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745752
Liu
LincRNAFEZF1-AS1 represses p2 ...
Homo sapiens
Mol. Cancer
16
39
2017
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1
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3
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1
1
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745771
Vyas
Lysine-specific demethylase-1 ...
Mus musculus
Mol. Cell. Neurosci.
82
1-11
2017
-
-
1
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1
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2
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1
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1
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2
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744347
Burg
Lysine-specific demethylase 1 ...
Homo sapiens
Biochemistry
55
1652-1662
2016
-
-
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3
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3
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1
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3
3
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6
1
1
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1
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-
744653
Zhao
H3K4me3 demethylase Kdm5a is ...
Mus musculus
Cell Rep.
15
288-299
2016
-
-
-
-
-
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2
1
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2
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3
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2
2
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744762
Mariani
The H3K4me3/2 histone demethy ...
Caenorhabditis elegans
Development
143
851-863
2016
-
-
1
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1
-
1
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1
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1
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2
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1
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4
4
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745354
Horton
Characterization of a linked ...
Homo sapiens
J. Biol. Chem.
291
2631-2646
2016
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1
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1
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3
1
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1
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6
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3
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1
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9
1
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3
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3
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9
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2
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6
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3
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9
3
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4
11
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745525
Bavetsias
8-Substituted pyrido[3,4-d]py ...
Homo sapiens
J. Med. Chem.
59
1388-1409
2016
-
-
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1
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66
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1
1
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5
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2
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2
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5
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1
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1
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1
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127
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2
2
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5
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4
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5
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2
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2
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745804
Popova
LSD1-mediated demethylation o ...
Mus musculus
Mol. Neurobiol.
53
4563-4581
2016
-
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1
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2
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1
1
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3
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2
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3
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3
3
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746464
Soloveychik
Mitochondrial control through ...
Saccharomyces cerevisiae
Sci. Rep.
6
37942
2016
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1
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2
1
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4
4
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746537
Xiao
Cadmium induces histone H3 ly ...
Homo sapiens
Toxicol. Sci.
145
80-89
2015
1
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1
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2
1
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744188
El Mansouri
Lysine-specific demethylase 1 ...
Homo sapiens
Arthritis Res. Ther.
16
R113
2014
1
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1
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1
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2
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1
1
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2
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1
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3
3
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744589
Ryu
Yeast histone H3 lysine 4 dem ...
Saccharomyces cerevisiae
BMC Biol.
12
75
2014
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1
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2
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1
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1
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4
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744657
Klein
The histone-H3K4-specific dem ...
Homo sapiens
Cell Rep.
6
325-335
2014
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1
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3
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2
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4
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1
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14
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14
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4
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744990
Shen
Over-expression of histone H3 ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Front. Plant Sci.
5
290
2014
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1
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1
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6
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2
2
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745309
Nishibuchi
Physical and functional inter ...
Caenorhabditis elegans, Homo sapiens
J. Biol. Chem.
289
28956-28970
2014
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2
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1
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4
2
1
6
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3
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1
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2
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8
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1
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2
1
6
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1
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8
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6
6
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746266
Yokoo
Se14, encoding a JmjC domain- ...
Oryza sativa Japonica Group
PLoS ONE
9
e96064
2014
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1
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1
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2
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1
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3
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3
3
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724667
Grafodatskaya
Multilocus loss of DNA methyla ...
Homo sapiens
BMC Med. Genomics
6
0000
2013
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1
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LSD1 demethylates histone and ...
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The lysine demethylase LSD1 (K ...
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Cui
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DNA oxidation as triggered by ...
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Histone H3K4 demethylases are ...
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Klose
The retinoblastoma binding pro ...
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Secombe
The function and regulation of ...
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Yamane
PLU-1 is an H3K4 demethylase i ...
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689143
Eissenberg
The trithorax-group gene in Dr ...
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689149
Tahiliani
The histone H3K4 demethylase S ...
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Xiang
JARID1B is a histone H3 lysine ...
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Huang
Inhibition of lysine-specific ...
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Metzger
LSD1 demethylates repressive h ...
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