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Literature summary for 1.14.11.8 extracted from

  • Hulse, J.D.; Ellis, S.R.; Henderson, L.M.
    Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase (1978), J. Biol. Chem., 253, 1654-1659.
    View publication on PubMed
Search for more literature for 1.14.11.8

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
additional information no activity found in microsomal or soluble fractions of liver Rattus norvegicus
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-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 Rattus norvegicus carnitine biosynthesis 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 N6,N6, N6-trimethyl-L-lysine is epsilon-N-trimethyl-L-lysine Rattus norvegicus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 carnitine biosynthesis Rattus norvegicus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?

Cofactor

Cofactor Comment Organism Structure
ascorbate required Rattus norvegicus