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Literature summary for 1.14.11.79 extracted from

  • Ge, W.; Wolf, A.; Feng, T.; Ho, C.; Sekirnik, R.; Zayer, A.; Granatino, N.; Cockman, M.; Loenarz, C.; Loik, N.; Hardy, A.; Claridge, T.; Hamed, R.; Chowdhury, R.; Gong, L.; Robinson, C.; Trudgian, D.; Jiang, M.; MacKeen, M.; McCullagh, J.; Gordiyenko, Y.
    Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans (2012), Nat. Chem. Biol., 8, 960-962 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.79

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleolus
-
 Homo sapiens 5730
-
ribosome
-
 Homo sapiens 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens HXHR is the preferred motif for hydroxylation ?
-
-
[Rpl27a]-L-histidine39 + 2-oxoglutarate + O2 Homo sapiens substrate i.e. 60S ribosomal protein [Rpl27a]-(3S)-3-hydroxy-L-histidine39 + succinate + CO2
-
 ?
[Rpl8]-L-histidine216 + 2-oxoglutarate + O2 Homo sapiens substrate i.e. 60S ribosomal protein [Rpl8]-(3S)-3-hydroxy-L-histidine216 + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IUF8 isoform Riox2
-
Homo sapiens Q9H6W3 isoform Riox1, cf. EC 1.14.11.27
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HXHR is the preferred motif for hydroxylation Homo sapiens ?
-
-
additional information NHXH is the preferred motif for hydroxylation Homo sapiens ?
-
-
[Rpl27a]-L-histidine39 + 2-oxoglutarate + O2 substrate i.e. 60S ribosomal protein Homo sapiens [Rpl27a]-(3S)-3-hydroxy-L-histidine39 + succinate + CO2
-
 ?
[Rpl8]-L-histidine216 + 2-oxoglutarate + O2 substrate i.e. 60S ribosomal protein Homo sapiens [Rpl8]-(3S)-3-hydroxy-L-histidine216 + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
C14orf169
-
 Homo sapiens
MAPJD
-
 Homo sapiens
MDIG
-
 Homo sapiens
MINA
-
 Homo sapiens
MINA53
-
 Homo sapiens
NO52
-
 Homo sapiens
NO66
-
 Homo sapiens
RIOX1
-
 Homo sapiens
RIOX2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme catalyzes the hydroxylation of L-histidine residues in the 60S ribosomal protein Rpl8. Also catalyzes histone L-lysine demethylation activities, demethylates histone H3 residues H3K4me and H3K36me, i.e. activities of ECs 1.14.11.67 and 1.14.11.27, respectively Homo sapiens
physiological function enzyme catalyzes the hydroxylation of L-histidine residues in the 60S ribosomal protein Rpl8. Also catalyzes histone L-lysine demethylation activities, demethylates histone H3 residues H3K9me3, i.e. activity of EC 1.14.11.66 Homo sapiens