Literature summary for 1.14.11.78 extracted from

Ali, H.; Ghafoor, S.; de Visser, S.
Density functional theory study into the reaction mechanism of isonitrile biosynthesis by the nonheme iron enzyme ScoE (2022), Top. Catal., 65, 528-543 .

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces coeruleorubidus	A0A3B6UEU3	-	-

General Information

General Information	Comment	Organism
metabolism	isonitrile can only be formed through two consecutive catalytic cycles that both use one molecule of dioxygen and 2-oxoglutarate. In both cycles the active species is an iron(IV)-oxo species that in the first reaction cycle reacts through two consecutive hydrogen atom abstraction steps, first from the N-H group and thereafter from the C-H group to desaturate the NH-CH2 bond. The electronic configurations along that pathway implicate an initial hydride transfer followed by proton transfer. A second catalytic cycle of the reaction of iron(IV)-oxo with desaturated substrate starts with hydrogen atom abstraction followed by decarboxylation to give isonitrile directly	Streptomyces coeruleorubidus

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Release 2023.1 (January 2023)