Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium marinum | - |
- |
- |
Streptomyces coeruleorubidus | A0A3B6UEU3 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
mmaE | - |
Mycobacterium marinum |
scoE | - |
Streptomyces coeruleorubidus |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme is involved in the biosynthesis of isonitrile lipopeptides (INLPs) through a thio-template mechanism. Deletion of INLP biosynthetic genes decreases the intracellular metal concentration | Mycobacterium marinum |
physiological function | enzyme is involved in the biosynthesis of isonitrile lipopeptides (INLPs) through a thio-template mechanism. Isonitrile is generated from a single precursor Gly by a thioesterase and nonheme iron(II)-dependent oxidase ScoE. ScoD catalyzes a Michael addition of Gly to the beta-position of an alpha,beta-unsaturated fatty acyl-ACP to yield an N-carboxymethyl-3-aminoacyl-ACP. ScoE catalyzes the subsequent oxidation and decarboxylation to yield a beta-isonitrile moiety | Streptomyces coeruleorubidus |