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Literature summary for 1.14.11.78 extracted from

  • Harris, N.; Sato, M.; Herman, N.; Twigg, F.; Cai, W.; Liu, J.; Zhu, X.; Downey, J.; Khalaf, R.; Martin, J.; Koshino, H.; Zhang, W.
    Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria (2017), Proc. Natl. Acad. Sci. USA, 114, 7025-7030 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mycobacterium marinum
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Streptomyces coeruleorubidus A0A3B6UEU3
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Synonyms

Synonyms Comment Organism
mmaE
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Mycobacterium marinum
scoE
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Streptomyces coeruleorubidus

General Information

General Information Comment Organism
physiological function enzyme is involved in the biosynthesis of isonitrile lipopeptides (INLPs) through a thio-template mechanism. Deletion of INLP biosynthetic genes decreases the intracellular metal concentration Mycobacterium marinum
physiological function enzyme is involved in the biosynthesis of isonitrile lipopeptides (INLPs) through a thio-template mechanism. Isonitrile is generated from a single precursor Gly by a thioesterase and nonheme iron(II)-dependent oxidase ScoE. ScoD catalyzes a Michael addition of Gly to the beta-position of an alpha,beta-unsaturated fatty acyl-ACP to yield an N-carboxymethyl-3-aminoacyl-ACP. ScoE catalyzes the subsequent oxidation and decarboxylation to yield a beta-isonitrile moiety Streptomyces coeruleorubidus