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Literature summary for 1.14.11.7 extracted from

  • Pignata, P.; Apicella, I.; Cicatiello, V.; Puglisi, C.; Magliacane Trotta, S.; Sanges, R.; Tarallo, V.; De Falco, S.
    Prolyl 3-hydroxylase 2 is a molecular player of angiogenesis (2021), Int. J. Mol. Sci., 22, 3896 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.7

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[procollagen]-L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
-
 ?
[procollagen]-L-proline + 2-oxoglutarate + O2 Mus musculus
-
 [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IVL5
-
-
Mus musculus Q8CG71
-
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelial cell
-
 Homo sapiens
-
umbilical vein endothelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[procollagen]-L-proline + 2-oxoglutarate + O2
-
 Homo sapiens [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
-
 ?
[procollagen]-L-proline + 2-oxoglutarate + O2
-
 Mus musculus [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
P3H2
-
 Homo sapiens
P3H2
-
 Mus musculus
prolyl 3-hydroxylase 2
-
 Homo sapiens
prolyl 3-hydroxylase 2
-
 Mus musculus

General Information

General Information Comment Organism
drug target the enzyme could be considered as a potential target for anti-angiogenesis therapy Homo sapiens
drug target the enzyme could be considered as a potential target for anti-angiogenesis therapy Mus musculus
physiological function P3H2 is involved in formation of new vessels. The enzyme catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly on type IV. Through its activity on type IV collagen, the enzyme is essential for angiogenesis properties of endothelial cells in vitro by performing experiments of gain- and loss-of-function. Overexpression of P3H2 induces a more condensed status of Collagen IV, accompanied by an alignment of the cells along the Collagen IV bundles, so towards an evident pro-angiogenic status Homo sapiens
physiological function P3H2 is involved in formation of new vessels. The enzyme catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly on type IV. Through its activity on type IV collagen, the enzyme is essential for angiogenesis properties of endothelial cells in vitro by performing experiments of gain- and loss-of-function. Overexpression of P3H2 induces a more condensed status of Collagen IV, accompanied by an alignment of the cells along the Collagen IV bundles, so towards an evident pro-angiogenic status Mus musculus