BRENDA - Enzyme Database
show all sequences of 1.14.11.7

Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate

Majamaa, K.; Turpeenniemi-Hujanen, T.M.; Latipää, P.; Gunzler, V.; Hanauske-Abel, H.M.; Hassinen, I.E.; Kivirikko, K.I.; Biochem. J. 229, 127-133 (1985)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-oxoadipate
-
Gallus gallus
2-oxobutyrate
-
Gallus gallus
2-oxpentanoate
-
Gallus gallus
3-oxoglutarate
-
Gallus gallus
adipate
-
Gallus gallus
benzene-1,2-dicarboxylate
-
Gallus gallus
Benzene-1,3-dicarboxylate
-
Gallus gallus
Benzene-1,4-dicarboxylate
-
Gallus gallus
Benzoate
-
Gallus gallus
Glutarate
-
Gallus gallus
laevulinate
-
Gallus gallus
malonate
-
Gallus gallus
oxaloacetate
-
Gallus gallus
pyridine-2,3-dicarboxylate
-
Gallus gallus
Pyridine-2,4-dicarboxylate
-
Gallus gallus
Pyridine-2,5-dicarboxylate
-
Gallus gallus
pyridine-2-carboxylate
-
Gallus gallus
pyridine-3,4-dicarboxylate
-
Gallus gallus
pyridine-3,5-dicarboxylate
-
Gallus gallus
pyridine-3-carboxylate
-
Gallus gallus
pyridine-4-carboxylate
-
Gallus gallus
pyruvate
-
Gallus gallus
succinate
-
Gallus gallus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Gallus gallus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
embryo
-
Gallus gallus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
procollagen L-proline + 2-oxoglutarate + O2
proline-labelled polypeptide substrate
349014
Gallus gallus
procollagen trans-3-hydroxy-L-proline + succinate + CO2
-
-
-
?
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.003
-
Pyridine-2,4-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.015
-
Pyridine-2,5-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.2
-
pyridine-2-carboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.3
-
pyridine-3-carboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
Benzene-1,3-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
Benzene-1,4-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
oxaloacetate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
pyridine-3,5-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
pyridine-3-carboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.7
-
pyridine-2,3-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.8
-
succinate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
1
-
2-oxoadipate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
1.3
-
benzene-1,2-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
2
-
pyridine-3,4-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
2.8
-
3-oxoglutarate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
3.1
-
Benzoate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
3.6
-
Glutarate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
4.2
-
pyruvate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
6
-
adipate
-
Gallus gallus
7.4
-
malonate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
8
-
laevulinate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
9.9
-
2-oxobutyrate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
15
-
2-Oxopentanoate
above, competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-oxoadipate
-
Gallus gallus
2-oxobutyrate
-
Gallus gallus
2-oxpentanoate
-
Gallus gallus
3-oxoglutarate
-
Gallus gallus
adipate
-
Gallus gallus
benzene-1,2-dicarboxylate
-
Gallus gallus
Benzene-1,3-dicarboxylate
-
Gallus gallus
Benzene-1,4-dicarboxylate
-
Gallus gallus
Benzoate
-
Gallus gallus
Glutarate
-
Gallus gallus
laevulinate
-
Gallus gallus
malonate
-
Gallus gallus
oxaloacetate
-
Gallus gallus
pyridine-2,3-dicarboxylate
-
Gallus gallus
Pyridine-2,4-dicarboxylate
-
Gallus gallus
Pyridine-2,5-dicarboxylate
-
Gallus gallus
pyridine-2-carboxylate
-
Gallus gallus
pyridine-3,4-dicarboxylate
-
Gallus gallus
pyridine-3,5-dicarboxylate
-
Gallus gallus
pyridine-3-carboxylate
-
Gallus gallus
pyridine-4-carboxylate
-
Gallus gallus
pyruvate
-
Gallus gallus
succinate
-
Gallus gallus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.003
-
Pyridine-2,4-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.015
-
Pyridine-2,5-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.2
-
pyridine-2-carboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.3
-
pyridine-3-carboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
Benzene-1,3-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
Benzene-1,4-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
oxaloacetate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
pyridine-3,5-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.5
-
pyridine-3-carboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.7
-
pyridine-2,3-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
0.8
-
succinate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
1
-
2-oxoadipate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
1.3
-
benzene-1,2-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
2
-
pyridine-3,4-dicarboxylate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
2.8
-
3-oxoglutarate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
3.1
-
Benzoate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
3.6
-
Glutarate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
4.2
-
pyruvate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
6
-
adipate
-
Gallus gallus
7.4
-
malonate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
8
-
laevulinate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
9.9
-
2-oxobutyrate
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
15
-
2-Oxopentanoate
above, competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
Gallus gallus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
embryo
-
Gallus gallus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
procollagen L-proline + 2-oxoglutarate + O2
proline-labelled polypeptide substrate
349014
Gallus gallus
procollagen trans-3-hydroxy-L-proline + succinate + CO2
-
-
-
?
Other publictions for EC 1.14.11.7
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745337
Hudson
Post-translationally abnormal ...
Mus musculus
J. Biol. Chem.
290
8613-8622
2015
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3
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2
2
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746168
Homan
Differential effects of colla ...
Mus musculus
PLoS Genet.
10
e1004121
2014
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1
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5
1
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1
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3
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1
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1
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1
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2
2
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746295
Pokidysheva
Biological role of prolyl 3-h ...
Mus musculus
Proc. Natl. Acad. Sci. USA
111
161-166
2014
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1
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1
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1
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-
2
2
-
-
-
727956
Pokidysheva
Posttranslational modification ...
Mus musculus
J. Biol. Chem.
288
24742-24752
2013
-
-
-
-
-
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-
-
-
-
-
-
-
3
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3
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3
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-
-
-
-
-
-
1
1
-
-
-
727931
Fujita
Prolyl hydroxylase 3 (PHD3) mo ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
287
39942-39953
2012
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-
-
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2
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2
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2
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-
2
2
2
2
-
-
728198
Chen
Roles of individual prolyl-4-h ...
Mus musculus
J. Physiol.
590
4079-4091
2012
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1
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1
1
-
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727884
Fernandes
A role for prolyl 3-hydroxylas ...
Rattus norvegicus
J. Biol. Chem.
286
30662-30669
2011
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-
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1
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1
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1
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1
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1
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1
1
-
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711115
Liu
Prolyl hydroxylase 3 interacts ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
401
231-237
2010
-
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2
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1
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1
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1
2
2
1
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-
712433
Vranka
Prolyl 3-hydroxylase 1 null mi ...
Mus musculus
J. Biol. Chem.
285
17253-17262
2010
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1
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5
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7
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1
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1
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7
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1
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1
1
-
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-
697017
Shah
The prolyl 3-hydroxylases P3H2 ...
Homo sapiens
Br. J. Cancer
100
1687-1696
2009
-
-
1
-
1
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2
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1
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2
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1
2
4
2
-
-
697189
Vranka
Expression of prolyl 3-hydroxy ...
Mus musculus
Cell Struct. Funct.
34
97-104
2009
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-
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3
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5
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6
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3
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3
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16
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3
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697192
Marini
Null mutations in LEPRE1 and C ...
Homo sapiens
Cell Tissue Res.
339
59-70
2009
-
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1
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1
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1
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1
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2
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1
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2
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1
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1
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1
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1
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1
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-
2
-
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-
-
-
-
-
-
1
1
-
-
-
698181
Chang
Prolyl 3-hydroxylase 1 and CRT ...
Homo sapiens
Hum. Mol. Genet.
19
223-234
2009
-
-
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-
1
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1
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2
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1
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1
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1
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1
1
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698909
Ishikawa
Biochemical characterization o ...
Gallus gallus
J. Biol. Chem.
284
17641-17647
2009
-
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1
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1
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1
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1
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1
1
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2
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1
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1
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1
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1
1
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2
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