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Literature summary for 1.14.11.7 extracted from

  • Majamaa, K.; Turpeenniemi-Hujanen, T.M.; Latipää, P.; Gunzler, V.; Hanauske-Abel, H.M.; Hassinen, I.E.; Kivirikko, K.I.
    Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate (1985), Biochem. J., 229, 127-133.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-oxoadipate
-
Gallus gallus
2-oxobutyrate
-
Gallus gallus
2-oxpentanoate
-
Gallus gallus
3-oxoglutarate
-
Gallus gallus
adipate
-
Gallus gallus
benzene-1,2-dicarboxylate
-
Gallus gallus
Benzene-1,3-dicarboxylate
-
Gallus gallus
Benzene-1,4-dicarboxylate
-
Gallus gallus
benzoate
-
Gallus gallus
Glutarate
-
Gallus gallus
laevulinate
-
Gallus gallus
malonate
-
Gallus gallus
oxaloacetate
-
Gallus gallus
pyridine-2,3-dicarboxylate
-
Gallus gallus
Pyridine-2,4-dicarboxylate
-
Gallus gallus
Pyridine-2,5-dicarboxylate
-
Gallus gallus
pyridine-2-carboxylate
-
Gallus gallus
pyridine-3,4-dicarboxylate
-
Gallus gallus
pyridine-3,5-dicarboxylate
-
Gallus gallus
pyridine-3-carboxylate
-
Gallus gallus
pyridine-4-carboxylate
-
Gallus gallus
pyruvate
-
Gallus gallus
succinate
-
Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 proline-labelled polypeptide substrate Gallus gallus procollagen trans-3-hydroxy-L-proline + succinate + CO2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.003
-
Pyridine-2,4-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.015
-
Pyridine-2,5-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.2
-
pyridine-2-carboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.3
-
pyridine-3-carboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.5
-
oxaloacetate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.5
-
pyridine-3-carboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.5
-
Benzene-1,3-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.5
-
Benzene-1,4-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.5
-
pyridine-3,5-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.7
-
pyridine-2,3-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
0.8
-
succinate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1
-
2-oxoadipate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
1.3
-
benzene-1,2-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
2
-
pyridine-3,4-dicarboxylate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
2.8
-
3-oxoglutarate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
3.1
-
benzoate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
3.6
-
Glutarate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
4.2
-
pyruvate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
6
-
adipate
-
Gallus gallus
7.4
-
malonate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
8
-
laevulinate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
9.9
-
2-oxobutyrate competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus
15
-
2-oxopentanoate above, competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate Gallus gallus