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Literature summary for 1.14.11.69 extracted from

  • Duan, L.; Perez, R.E.; Lai, X.; Chen, L.; Maki, C.G.
    The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells (2019), J. Biol. Chem., 294, 9186-9197 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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 Homo sapiens
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MHM cell
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 Homo sapiens
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SJSA-1 cell
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 Homo sapiens
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U2-OS cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function anticancer agent nutlin kills MDM2-amplified cancer cells by altering histone methylation in an MDM2 proto-oncogene-dependent manner. MDM2 amplification increases histone methylation in nutlin-treated cells by causing depletion of histone demethylase JMJD2B. JMJD2B knockdown or inhibition increases H3K9/K36me3 levels, decreases ATG gene expression and autophagy, and sensitizes MDM2-nonamplified cells to apoptosis Homo sapiens