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Literature summary for 1.14.11.69 extracted from

  • Kim, T.; Buratowski, S.
    Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation (2007), J. Biol. Chem., 282, 20827-20835 .
    View publication on PubMed
Search for more literature for 1.14.11.69

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome Rph1 associates with nucleosomes independently of H3 Lys36 methylation Saccharomyces cerevisiae 786
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2 Saccharomyces cerevisiae
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 [histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
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 ?
[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2 Saccharomyces cerevisiae
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 [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2 Saccharomyces cerevisiae
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 [histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P39956
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine36 + 2 2-oxoglutarate + 2 O2
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 Saccharomyces cerevisiae [histone H3]-N6-methyllysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyllysine36 + 2-oxoglutarate + O2
-
 Saccharomyces cerevisiae [histone H3]-N6,N6-dimethyllysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine36 + 2-oxoglutarate + O2
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 Saccharomyces cerevisiae [histone H3]-N6-methyllysine36 + succinate + formaldehyde + CO2
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 ?

Synonyms

Synonyms Comment Organism
DNA damage-responsive transcriptional repressor
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 Saccharomyces cerevisiae
Rph1
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function Rph1 functions as a specific demethylase for H3 K36me3 and K36me2, directly regulating Lys36 methylation in transcribed regions. Both JmjC-domain proteins Jhd1 and Rph1 are required for normal levels of RNA polymerase II crosslinking to genes. Overexpression of either Jhd1 or Rph1 bypasses the requirement for the positive elongation factor gene BUR1 Saccharomyces cerevisiae