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Literature summary for 1.14.11.69 extracted from

  • Lorbeck, M.T.; Singh, N.; Zervos, A.; Dhatta, M.; Lapchenko, M.; Yang, C.; Elefant, F.
    The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila (2009), Gene, 450, 8-17 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene KDM4A, DNA and amino acid sequence determination and analysis, quantitative PCR expression analysis and sequence comparisons Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Drosophila melanogaster 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2 Drosophila melanogaster
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[histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2 Drosophila melanogaster
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[histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9V333
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information Dmel\Kdm4A expression during development in comparison to other JMJD2 enzymes, overview Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctional enzyme specifically demethylates Lys9 (EC 1.14.11.66) and Lys36 residues of histone H3 Drosophila melanogaster ?
-
?
[histone H3]-N6,N6,N6-trimethyl-L-lysine 36 + 2-oxoglutarate + O2
-
Drosophila melanogaster [histone H3]-N6,N6-dimethyl-L-lysine 36 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyl-L-lysine 36 + 2-oxoglutarate + O2
-
Drosophila melanogaster [histone H3]-N6-methyl-L-lysine 36 + succinate + formaldehyde + CO2
-
?

Subunits

Subunits Comment Organism
More histone demethylase familiy enzymes domain structure comparisons, overview Drosophila melanogaster

Synonyms

Synonyms Comment Organism
CG15835
-
Drosophila melanogaster
Dmel\Kdm4A
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Drosophila melanogaster
KDM4A
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Drosophila melanogaster
lysine-specific demethylase 4A UniProt Drosophila melanogaster

General Information

General Information Comment Organism
evolution the Drosophila melanogaster HDM gene Dmel\Kdm4A is a homologue of the human JMJD2 family. Dmel\JHMD1, Dmel\JHMD2, and Dmel\Kdm4A are each highly conserved with their human homologue counterparts Drosophila melanogaster
malfunction disruption of Dmel\Kdm4A results in a reduction of the male life span and a male-specific wing extension/twitching phenotype that occurs in response to other males and is reminiscent of an inter-male courtship phenotype involving the courtship song, phenotypes overview. Certain genes associated with each of these phenotypes are significantly downregulated in response to Dmel\Kdm4A loss, most notably the longevity associated Hsp22 gene and the male sex-determination fruitless gene Drosophila melanogaster
physiological function histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila melanogaster. Essential role for Dmel\Kdm4A in the transcriptional activation of genes involved in the aging process and male-specific neuronal formation and courtship behavior Drosophila melanogaster