Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | Homo sapiens | - |
a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
additional information | Homo sapiens | JMJD2A demethylates trimethylated histone K9/K36 to di- but not mono- or unmethylated products, i.e. JMJD2A also catalyzes the reactions of EC 1.14.11.66, H3K9 trimethyl demethylase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | Q9U297 | - |
- |
Homo sapiens | O75164 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Homo sapiens | a [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
additional information | JMJD2A demethylates trimethylated histone K9/K36 to di- but not mono- or unmethylated products, i.e. JMJD2A also catalyzes the reactions of EC 1.14.11.66, H3K9 trimethyl demethylase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JMJD-2 | - |
Caenorhabditis elegans |
JMJD2A | - |
Homo sapiens |
KDM4 | - |
Caenorhabditis elegans |
KDM4A | - |
Homo sapiens |
lysine-specific demethylase 4A | - |
Homo sapiens |
lysine-specific demethylase 4A | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of JMJD2A reduces H3-K9/K36 trimethylation levels in cultured cells | Homo sapiens |
physiological function | RNAi depletion results in an increase in general trimethylation of H3-K9 and localizes H3-K36Me3 levels on meiotic chromosomes and triggers p53-dependent germline apoptosis | Caenorhabditis elegans |