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Literature summary for 1.14.11.69 extracted from
- Stimulating conversations between HP1a and histone demethylase dKDM4A (2008), Mol. Cell, 32, 601-602.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heterochromatin protein 1 | predominant localization to centric heterochromatin. HP1a, when resident near centromeres, plays a role in the gene silencing associated with heterochromatin packaging. HP1a binding, two molecules HP1a per enzyme molecule, stimulates demethylation of H3K36me2 and H3K36me3 by dKDM4a, mechanism, overview. HP1a mutant V26M is inactive | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | Drosophila melanogaster | JmjC domain-containing protein dKDM4A is a histone H3K36 demethylase. Histone H3 methylation is one of the consistent marks distinguishing alternative chromatin packaging states | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
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Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | - |
Drosophila melanogaster | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | JmjC domain-containing protein dKDM4A is a histone H3K36 demethylase. Histone H3 methylation is one of the consistent marks distinguishing alternative chromatin packaging states | Drosophila melanogaster | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dKDM4A | - |
Drosophila melanogaster |
| H3K36 histone demethylase | - |
Drosophila melanogaster |
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