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Literature summary for 1.14.11.68 extracted from

  • Agger, K.; Cloos, P.A.; Christensen, J.; Pasini, D.; Rose, S.; Rappsilber, J.; Issaeva, I.; Canaani, E.; Salcini, A.E.; Helin, K.
    UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development (2007), Nature, 449, 731-734 .
    View publication on PubMed
Search for more literature for 1.14.11.68

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2 Homo sapiens
-
 [histone H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q95QK3
-
-
Homo sapiens O15054
-
-
Homo sapiens O15550
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?
a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2
-
 Homo sapiens a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2
-
 Homo sapiens [histone H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
F18E9.5
-
 Caenorhabditis elegans
jmjd-3.1
-
 Caenorhabditis elegans
JMJD3
-
 Homo sapiens
KDM6A
-
 Homo sapiens
KDM6B
-
 Homo sapiens
lysine-specific demethylase 6A
-
 Homo sapiens
lysine-specific demethylase 6B
-
 Homo sapiens
UTX
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3. Ectopic expression of JMJD3 leads to a strong decrease of H3K27me3 levels and causes delocalization of polycomb proteins in vivo. H3K27me3 demethylation regulated by UTX/JMJD3 proteins is essential for proper development Homo sapiens
physiological function JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3. H3K27me3 demethylation regulated by UTX/JMJD3 proteins is essential for proper development Homo sapiens
physiological function mutation of JMJD3 orthologue, or inhibition of its expression, results in abnormal gonad development Caenorhabditis elegans