Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.68 extracted from

  • Lan, F.; Bayliss, P.E.; Rinn, J.L.; Whetstine, J.R.; Wang, J.K.; Chen, S.; Iwase, S.; Alpatov, R.; Issaeva, I.; Canaani, E.; Roberts, T.M.; Chang, H.Y.; Shi, Y.
    A histone H3 lysine 27 demethylase regulates animal posterior development (2007), Nature, 449, 689-694 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Danio rerio A1L1S9 isoform Utx1
-
Homo sapiens O15550
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast UTX is enriched around the transcription start sites of many HOX genes in primary human fibroblasts Homo sapiens
-
additional information UTX is selectively excluded from the HOX loci in embryonic stem cells, in which HOX genes are largely silent Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyllysine27 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6,N6-dimethyllysine27 + succinate + formaldehyde + CO2
-
?
[histone H3]-N6,N6-dimethyllysine27 + 2-oxoglutarate + O2
-
Homo sapiens [histone H3]-N6-methyllysine27 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
Kdm6al
-
Danio rerio
UTX1
-
Danio rerio

General Information

General Information Comment Organism
physiological function inhibition of Utx1 results in misregulation of hox genes and a striking posterior developmental defect, which is partially rescued by wild-type, but not by catalytically inactive, human Utx Danio rerio
physiological function RNAi inhibition of UTX leads to increased H3K27me3 levels at some HOX gene promoters Homo sapiens