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Literature summary for 1.14.11.68 extracted from

  • Chen, S.; Ma, J.; Wu, F.; Xiong, L.J.; Ma, H.; Xu, W.; Lv, R.; Li, X.; Villen, J.; Gygi, S.P.; Liu, X.S.; Shi, Y.
    The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation (2012), Genes Dev., 26, 1364-1375 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens O15054
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [histine H3]-N6,N6,N6-trimethyllysine27 + 2 2-oxoglutarate + 2 O2
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 Homo sapiens a [histine H3]-N6-methyllysine27 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

General Information

General Information Comment Organism
physiological function JMJD3 is associated with demethylase KIAA1718. JMJD3 and KIAA1718 directly bind to and regulate the expression of a plethora of common target genes in both a demethylase activity-dependent and -independent manner. JMJD3 and KIAA1718 collaborate to demethylate trimethylated H3K27 (H3K27me3) on a subset of their target genes. Reduction of either JMJD3 or KIAA1718 diminishes polymerase Pol II traveling along the gene bodies of the affected genes while having no effect on the promoter-proximal Pol II. JMJD3 and KIAA1718 also play a role in localizing elongation factors SPT6 and SPT16 to the target genes Homo sapiens