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Literature summary for 1.14.11.68 extracted from

  • Pan, D.; Huang, L.; Zhu, L.J.; Zou, T.; Ou, J.; Zhou, W.; Wang, Y.X2
    Jmjd3-mediated H3K27me3 dynamics orchestrate brown fat development and regulate white fat plasticity (2015), Dev. Cell, 35, 568-583 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q5NCY0
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Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
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Mus musculus
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preadipocyte
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Mus musculus
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General Information

General Information Comment Organism
physiological function Jmjd3 is involved in brown fat development and white fat browning. A significant subset of brown fat-selective genes, but not common fat genes or white fat-selective genes, are demarcated by H3K27me3 in both brown and white preadipocytes. Jmjd3-catalyzed removal of H3K27me3, in part through Rreb1-mediated recruitment, is required for expression of brown fat-selective genes and for development of beige adipocytes both in vitro and in vivo. Gain- and loss-of-function Jmjd3 transgenic mice show age-dependent body weight reduction and cold intolerance, respectively Mus musculus