Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q5NCY0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Mus musculus | - |
preadipocyte | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | Jmjd3 is involved in brown fat development and white fat browning. A significant subset of brown fat-selective genes, but not common fat genes or white fat-selective genes, are demarcated by H3K27me3 in both brown and white preadipocytes. Jmjd3-catalyzed removal of H3K27me3, in part through Rreb1-mediated recruitment, is required for expression of brown fat-selective genes and for development of beige adipocytes both in vitro and in vivo. Gain- and loss-of-function Jmjd3 transgenic mice show age-dependent body weight reduction and cold intolerance, respectively | Mus musculus |