Literature summary for 1.14.11.68 extracted from

Xiang, Y.; Zhu, Z.; Han, G.; Lin, H.; Xu, L.; Chen, C.D.
JMJD3 is a histone H3K27 demethylase (2007), Cell Res., 17, 850-857 .

Search for more literature for 1.14.11.68

Application

Application	Comment	Organism
medicine	JMJD3 is upregulated in prostate cancer, and its expression is higher in metastatic prostate cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15054	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	no substrates: methylated histone residues H3K4 and H3K9	Homo sapiens	?	-	?

Expression

Organism	Comment	Expression
Homo sapiens	JMJD3 is upregulated in prostate cancer, and its expression is higher in metastatic prostate cancer	up

General Information

General Information	Comment	Organism
physiological function	transfection of JMJD3 into HeLa cells causes a specific reduction of trimethyl H3K27, but has no effect on di- and monomethyl H3K27, or histone lysine methylations on H3K4 and H3K9. The enzymatic activity requires the JmjC domain. JMJD3 directly catalyzes the demethylation	Homo sapiens

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Release 2023.1 (January 2023)