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Literature summary for 1.14.11.68 extracted from

  • Burgold, T.; Voituron, N.; Caganova, M.; Tripathi, P.P.; Menuet, C.; Tusi, B.K.; Spreafico, F.; Bevengut, M.; Gestreau, C.; Buontempo, S.; Simeone, A.; Kruidenier, L.; Natoli, G.; Casola, S.; Hilaire, G.; Testa, G.
    The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival (2012), Cell Rep., 2, 1244-1258 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Mus musculus Q5NCY0
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General Information

General Information Comment Organism
physiological function loss of Jmjd3 activity causes perinatal lethality with the complete and selective disruption of the pre-Boetzinger complex, the pacemaker of the respiratory rhythm generator. Jmjd3-null mice die at birth of respiratory failure. The enzymatic activity of Jmjd3 is selectively required for the maintenance of the pre-Boetzinger complex and controls critical regulators of pre-Boetzinger complex activity Mus musculus