Literature summary for 1.14.11.66 extracted from

Choi, J.H.; Lee, H.
Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells (2020), Sci. Rep., 10, 3050 .

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Application

Application	Comment	Organism
medicine	KDM4D is a key regulator of adipogenesis in C3H10T1/2 mesenchymal stem cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q3U2K5	isoform KDM4D	-

Synonyms

Synonyms	Comment	Organism
KDM4D	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	KDM4D is a key regulator of adipogenesis in C3H10T1/2 mesenchymal stem cells. The depletion of KDM4D results in impaired differentiation, which can be rescued by exogenous KDM4D, PPARgamma, and C/EBPalpha, but not by C/EBPbeta. KDM4D interacts physically and functionally with both NFIB and MLL1 complex to regulate C/EBPalpha and PPARgamma expression upon adipogenic hormonal induction. KDM4D is dispensable for the binding of both NFIB and MLL1 complex to the target promoters, but the demethylation of trimethylated H3K9 by KDM4D is required for NFIB and MLL1 complex to deposit trimethylated H3K4 and activate PPARgamma and C/EBPalpha expression	Mus musculus

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Release 2023.1 (January 2023)