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Literature summary for 1.14.11.66 extracted from

  • Hu, F.; Li, H.; Liu, L.; Xu, F.; Lai, S.; Luo, X.; Hu, J.; Yang, X.
    Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1beta/VEGFA signalling (2018), Mol. Cancer, 17, 107 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine a significant upregulation of KDM4D is observed in gastrointestinal stromal tumour tissue compared with matched normal tissue. KDM4D directly interacts with the HIF1beta gene promoter and regulates its activity, promoting tumour angiogenesis and gastrointestinal stromal tumour progression both in vitro and in vivo. KDM4D transcriptionally activates HIF1beta expression via H3K9me3 and H3K36me3 demethylation at the promoter region Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6B0I6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastrointestinal stromal tumor cell
-
 Homo sapiens
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stomach
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
KDM4D
-
 Homo sapiens
lysine-specific demethylase 4D
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens a significant upregulation of KDM4D is observed in gastrointestinal stromal tumour tissue compared with matched normal tissue up