Application | Comment | Organism |
---|---|---|
medicine | a significant upregulation of KDM4D is observed in gastrointestinal stromal tumour tissue compared with matched normal tissue. KDM4D directly interacts with the HIF1beta gene promoter and regulates its activity, promoting tumour angiogenesis and gastrointestinal stromal tumour progression both in vitro and in vivo. KDM4D transcriptionally activates HIF1beta expression via H3K9me3 and H3K36me3 demethylation at the promoter region | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6B0I6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastrointestinal stromal tumor cell | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
KDM4D | - |
Homo sapiens |
lysine-specific demethylase 4D | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | a significant upregulation of KDM4D is observed in gastrointestinal stromal tumour tissue compared with matched normal tissue | up |