Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.66 extracted from

  • Agger, K.; Nishimura, K.; Miyagi, S.; Messling, J.E.; Rasmussen, K.D.; Helin, K.
    The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance (2019), Blood, 134, 1154-1158 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.66

Organism

Organism UniProt Comment Textmining
Mus musculus Q91VY5 isoform KDM4B, cf. EC 1.14.11.69
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Mus musculus
-
peripheral blood cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
KDM4B
-
 Mus musculus

General Information

General Information Comment Organism
physiological function KDM4 activity is required for hematopoietic stem cell (HSC) maintenance in vivo. The combined knockout of Kdm4a, Kdm4b, and Kdm4c leads to reduction of myeloid and lymphoid cells. In conditional KDM4A/B/C triple-knockout mice, the knockout leads to accumulation of H3K9me3 on transcription start sites and the corresponding downregulation of expression of several genes in HSCs. Genes Taf1b and Nom1, are essential for the maintenance of hematopoietic cells Mus musculus