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Literature summary for 1.14.11.66 extracted from

  • Kim, T.D.; Oh, S.; Shin, S.; Janknecht, R.
    Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D (2012), PLoS ONE, 7, e34618 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.66

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme also demethylates lysine 26 at histone H1.4 ?
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 3 2-oxoglutarate + 3 O2 Homo sapiens overall reaction [histone H3]-L-lysine9 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme also demethylates lysine 26 at histone H1.4 Homo sapiens ?
-
-
additional information no activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine36 Homo sapiens ?
-
-
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 3 2-oxoglutarate + 3 O2 overall reaction Homo sapiens [histone H3]-L-lysine9 + 3 succinate + 3 formaldehyde + 3 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JMJD2D
-
 Homo sapiens
KDM4D
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme downregulation inhibits cell proliferation in wild type and even more so in p53-deficient HCT-116 colon cancer cells. Enzyme depletion also induces more strongly apoptosis in p53-deficient compared to wild-type HCT-116 cells Homo sapiens
physiological function the enzyme protects HCT-116 cells from apoptosis Homo sapiens