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Literature summary for 1.14.11.66 extracted from

  • Klose, R.J.; Yamane, K.; Bae, Y.; Zhang, D.; Erdjument-Bromage, H.; Tempst, P.; Wong, J.; Zhang, Y.
    The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36 (2006), Nature, 442, 312-316 .
    View publication on PubMed
Search for more literature for 1.14.11.66

Protein Variants

Protein Variants Comment Organism
H188A inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 Homo sapiens 35% demethylation activity [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens 80% demethylation activity [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Homo sapiens 25% demethylation activity [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens 30% demethylation activity [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 35% demethylation activity Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 80% demethylation activity Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 25% demethylation activity Homo sapiens [histone H3]-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 30% demethylation activity Homo sapiens [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
JDHM3A
-
 Homo sapiens
JmjC-domain-containing histone demethylase 3A
-
 Homo sapiens
JMJD2A
-
 Homo sapiens
jumonji C-domaincontaining histone demethylase 3A
-
 Homo sapiens