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Literature summary for 1.14.11.66 extracted from

  • Bartova, E.; Stixova, L.; Galiova, G.; Harni?arova Horakova, A.; Legartova, S.; Kozubek, S.
    Mutant genetic background affects the functional rearrangement and kinetic properties of JMJD2b histone demethylase (2011), J. Mol. Biol., 405, 679-695.
    View publication on PubMed
Search for more literature for 1.14.11.66

Cloned(Commentary)

Cloned (Comment) Organism
expression of full-length GFP-tagged JMJD2b-GFP-1086 and truncated JMJD2b forms in mouse fibroblasts and in Escherichia coli strain DH5alpha Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mutant and truncated forms of JMJD2b densely occupy the nucleolar compartment of fibroblasts. The PHD Zn-fingers and Tudor domains are removed in truncated JMJD2b. Nuclear patterns of full-length JMJD2b in comparison with truncated and mutated forms of JMJD2b, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information histone methyltransferase SUV39h deficiency changes the association between endogenous JMJD2b and various histone marks at chromocenters, overview. The level of full-length JMJD2b at chromocenters was reduced, corresponding to a global decrease in JMJD2b and H3K9me3 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleolus
-
 Mus musculus 5730
-
nucleoplasm
-
 Mus musculus 5654
-
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus low level of JMJD2b in nucleoli is not associated with the high level of H3K9 methylation in this nuclear region ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast in wild-type fibroblasts, the chromatin of ribosomal genes, which is dense with H3K9 methylation, lacks JMJD2b-GFP-1086, while mutant and truncated forms of JMJD2b densely occupie the nucleolar compartment Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information low level of JMJD2b in nucleoli is not associated with the high level of H3K9 methylation in this nuclear region Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
JMJD2B
-
 Mus musculus
JMJD2b histone demethylase
-
 Mus musculus

General Information

General Information Comment Organism
additional information in cells with a deficiency in the histone methyltransferase SUV39h, the level of full-length JMJD2b at chromocenters is reduced, corresponding to a global decrease in JMJD2b and H3K9me3. The PHD Zn-fingers and Tudor domains, which are removed in truncated JMJD2b, are responsible for the aberrant JMJD2b function. Nuclear patterns of full-length JMJD2b in comparison with truncated and mutated forms of JMJD2b, overview Mus musculus
physiological function JMJD2b histone demethylase antagonizes H3K9me3 in the pericentromeric heterochromatin Mus musculus