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Literature summary for 1.14.11.66 extracted from

  • Strobl-Mazzulla, P.H.; Sauka-Spengler, T.; Bronner-Fraser, M.
    Histone demethylase JmjD2A regulates neural crest specification (2010), Dev. Cell, 19, 460-468.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.66

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged JmjD2A under the control beta-actin promoter in chicken fibroblasts Gallus gallus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of JmjD2A in fibroblasts specifically depletes H3K9me3 and H3K36me3. Loss of JmjD2A by knockdown leads to depletion of neural crest specifier genes, but causes no significant changes in the expression of several neural tube, ectodermal, neural plate, and border genes, or in markers of proliferation and apoptosis, overview Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Gallus gallus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Gallus gallus
-
 histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
additional information Gallus gallus JmjD2A is specific for H3K9me3 and H3K36me3 substrates in fibroblasts, and does not affect H3K27me3 methylation marks ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neural crest
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Gallus gallus histone H3 N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?
additional information JmjD2A is specific for H3K9me3 and H3K36me3 substrates in fibroblasts, and does not affect H3K27me3 methylation marks Gallus gallus ?
-
 ?

Synonyms

Synonyms Comment Organism
histone demethylase JmjD2A
-
 Gallus gallus
JMJD2A
-
 Gallus gallus

General Information

General Information Comment Organism
additional information loss of JmjD2A leads to depletion of neural crest specifier genes, but causes no significant changes in the expression of several neural tube, ectodermal, neural plate, and border genes, or in markers of proliferation and apoptosis, overview Gallus gallus
physiological function JmjD2A is specific for H3K9me3 and H3K36me3 substrates in fibroblasts. H3K9me3 and H3K36me3 occupancy regulates neural crest specifier expression in vivo. Dynamic changes in both JmjD2A and H3K9me3 occupancy of the Sox10 promoter between stages 8 and 9 Gallus gallus