Application | Comment | Organism |
---|---|---|
medicine | histone demethylase JMJD2B is a therapeutic target in breast cancer patients | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
JMJD2B quantitative RT-PCR expression analysis, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-361 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
histone demethylase JMJD2B | - |
Homo sapiens |
JMJD2B | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | estrogen receptor alpha is important for JMJD2B expression in hypoxia, JMJD2B can be upregulated in hypoxia in an HIF-1alpha-dependent manner | up |
General Information | Comment | Organism |
---|---|---|
additional information | JMJD2B is important for breast cancer cell proliferation. JMJD2B and the hypoxia marker CA9 together stratify a subclass of breast cancer patients and predict a worse outcome of these breast cancers | Homo sapiens |
physiological function | JMJD2B regulates multiple biological processes including the cell cycle. The histone demethylase JMJD2B is regulated by both estrogen receptor alpha and HIF-1alpha, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1. Histone demethylase function of JMJD2B in hypoxia, overview | Homo sapiens |