Literature summary for 1.14.11.65 extracted from

Ding, G.; Xu, X.; Li, D.; Chen, Y.; Wang, W.; Ping, D.; Jia, S.; Cao, L.
Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation (2020), Cell Death Dis., 11, 893 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
fisetin	fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin	Homo sapiens

Application

Application	Comment	Organism
medicine	fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP expression is relatively low in PDAC and correlates with tumor stage and poor prognosis. Fisetin enhances the effect of chemotherapy on pancreatic cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75164	cf. EC 1.14.11.27, EC 1.14.11.69, EC 1.14.11.66	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BxPC-3 cell	-	Homo sapiens	-
HPC-Y5 cell	-	Homo sapiens	-
MiaPaCa-2 cell	-	Homo sapiens	-
PANC-1 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
KDM4A	-	Homo sapiens

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Release 2023.1 (January 2023)